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All Outputs (129)

Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy. Design: Two nested case-control studies. Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases.

Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article

Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin. Design: Prospective open cohort study. Settin... Read More about Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care.

Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study (2018)
Journal Article

Objective: To quantify psychological morbidity and identify baseline factors associated with depression, anxiety and post-traumatic distress symptoms up to 12 months post-injury. Methods: Multicentre cohort study of 668 adults, aged 16 to 70,... Read More about Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study.

Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets (2018)
Journal Article

Background: There is limited evidence on the safety of direct oral anticoagulants (DOACs) in real world settings. Aim: To investigate risks of bleeding and all-cause mortality in DOACs compared to warfarin. Method: Prospective cohorts of incide... Read More about Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets.

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article

© 2018 The Author(s). Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. Th... Read More about Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database.

Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study (2017)
Journal Article

Objectives: To derive and validate updated QDiabetes-2018 prediction algorithms to estimate the 10 year risk of type 2 diabetes in men and women, taking account of potential new risk factors, and to compare their performance with current approaches.... Read More about Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study.

Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study (2017)
Journal Article

Objectives: To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission. Design: Prospective open... Read More about Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study.

Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives (2017)
Journal Article

Background: Unintentional injuries among 0- to 4-year-olds are a major public health problem incurring substantial NHS, individual and societal costs. However, evidence on the effectiveness and cost-effectiveness of preventative interventions is lack... Read More about Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives.

Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study (2017)
Journal Article

Objective: To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design: Cohort study. Setting: General practices in England providing data for the QResea... Read More about Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study.

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study (2017)
Journal Article

Objectives: To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk factors. Design: Prospective open cohort study. Setting: General... Read More about Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study.

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More about Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study.