ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma

Nasir, Aishah; Cardall, Alice; Othman, Ramadhan T; Nicolaou, Niovi; Lourdusamy, Anbarasu; Linke, Franziska; Onion, David; Ryzhova, Marina; Cameron, Hanna; Valente, Cara; Korshunov, Andrey; Pfister, Stefan M; Grabowska, Anna M; Kerr, Ian D; Coyle, Beth

doi:10.1093/noajnl/vdab030

All Outputs (3)

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging (2021)
Journal Article

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapse... Read More about Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging.

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity (2021)
Journal Article

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role... Read More about CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma (2021)
Journal Article

Background: Therapeutic intervention in metastatic medulloblastoma is dependent upon elucidating the underlying metastatic mechanism. We investigated whether an epithelialmesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi... Read More about ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.