All Outputs (23)

Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells (2023)
Journal Article

Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. The aim of this study was to determine the effect of PIGR on cellular behaviours and chemo-sensiti... Read More about Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.

A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation (2022)
Journal Article

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes, but the relative contributions of different macronutrients is still unclear. We investigated the impact of fatty acids, glucose and fructose on lipid accumul... Read More about A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation.

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Integrins as a drug target in liver fibrosis (2022)
Journal Article

As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis-related morbidity and mortality. Integrins are heterodimeric cell-surface proteins that are promising... Read More about Integrins as a drug target in liver fibrosis.

Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release (2021)
Journal Article

Effective regenerative medicine requires delivery systems which can release multiple components at appropriate levels and at different phases of tissue growth and repair. However, there are few biomaterials and encapsulation techniques that are fully... Read More about Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release.

Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine (2021)
Journal Article

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammator... Read More about Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine.

Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men (2020)
Journal Article

Copyright © The Author(s) on behalf of the American Society for Nutrition 2020. BACKGROUND: Altering the temporal distribution of energy intake (EI) and introducing periods of intermittent fasting (IF) exert important metabolic effects. Restricting E... Read More about Two weeks of early time-restricted feeding (eTRF) improves skeletal muscle insulin and anabolic sensitivity in healthy men.

Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain (2020)
Journal Article

Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also... Read More about Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.

Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis (2018)
Journal Article

Objective: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium associated with symptomatic knee... Read More about Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis.

Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB (2018)
Journal Article

Adiposity and adipokines are implicated in the loss of skeletal muscle mass with age and in several chronic disease states. The aim of this study was to determine the effects of human obese and lean subcutaneous adipose tissue secretome on myogenesis... Read More about Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.

n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids (2018)
Journal Article

Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd... Read More about n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study (2018)
Journal Article

Background and Aims: The aims of this study were to identify whether differences in distribution of adipose tissue and skeletal muscle in obese and non-obese individuals contribute to the magnitude of the postoperative inflammatory response and insul... Read More about Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: a randomised controlled study.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

IL-15 promotes human myogenesis and mitigates the detrimental effects of TNF? on myotube development (2017)
Journal Article

Studies in murine cell lines and in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-mediated skeletal muscle atrophy which occurs in sarcopenia and cachexia. The effects of IL-15 on human skeletal muscle g... Read More about IL-15 promotes human myogenesis and mitigates the detrimental effects of TNF? on myotube development.

Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches (2017)
Journal Article

Short-term very low energy diets (VLED) are used in clinical practice prior to bariatric surgery, however, regimens vary and outcomes for a short intervention are unclear. We examined the effect of two VLEDs; a food-based diet (FD) and meal replaceme... Read More about Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: results of a randomised controlled trial (RCT) using two dietary approaches.

Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands (2017)
Journal Article

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combinat... Read More about Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models (2016)
Journal Article

Background Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behav... Read More about Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain (2016)
Journal Article

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this st... Read More about The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat (2014)
Journal Article

Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Her... Read More about Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.