All Outputs (5)

An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb (2007)
Journal Article
Wigginton, S. J., Furtado, P. B., Armour, K. L., Clark, M. R., Robins, A., Emara, M., …Shakib, F. (2008). An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb. Clinical and Experimental Allergy, 38(2), 313-319. https://doi.org/10.1111/j.1365-2222.2007.02896.x

Background: IgE binds to mast cells and basophils via its high-affinity receptor, FcεRI, and cross-linking of FcεRI-bound IgE molecules by allergen leads to the release of allergic mediators characteristic of type I hypersensitivity reactions. Previo... Read More about An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FcεRI with FcγRIIb.

Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome (2007)
Journal Article
Todd, I., Radford, P. M., Ziegler-Heitbrock, L., Ghaemmaghami, A. M., Powell, R. J., & Tighe, P. J. (2007). Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis and Rheumatism, 56(12), 4182-4188. https://doi.org/10.1002/art.23133

Objective. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an inherited autosomal-dominant autoinflammatory condition caused by mutations in the ectodomain of the 55-kd tumor necrosis factor (TNF) receptor superfamily 1A. Proin... Read More about Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome.

The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets (2007)
Journal Article
Richens, J., Fairclough, L., Ghaemmaghami, A. M., Mahdavi, J., Shakib, F., & Sewell, H. F. (2007). The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets. Immunobiology, 212(1), 29-38. https://doi.org/10.1016/j.imbio.2006.06.012

A disintegrin and metalloprotease (ADAM) proteins have wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion and intracellular signalling. Recent evidence suggests the involvement of ADAM8 in all... Read More about The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets.

Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics (2007)
Journal Article
Horlock, C., Shakib, F., Mahdavi, J., Jones, N. S., Sewell, H. F., & Ghaemmaghami, A. M. (2007). Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics. Genome Biology, 8(3), Article R30. https://doi.org/10.1186/gb-2007-8-3-r30

Background: Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood myeloid dendritic cells (mDCs) investigators have used differ... Read More about Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics.

The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses (2007)
Journal Article
Furmonaviciene, R., Ghaemmaghami, A. M., Boyd, S. E., Jones, N. S., Bailey, K., Willis, A. C., …Shakib, F. (2007). The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses. Clinical and Experimental Allergy, 37(2), 231-242. https://doi.org/10.1111/j.1365-2222.2007.02651.x

Background: The cysteine protease Der p 1 from the house dust mite Dermatophagoides pteronyssinus is one of the most potent allergens known. An attractive mechanism for a component of Der p 1 allergenicity lies in its ability to cleave key regulatory... Read More about The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses.