All Outputs (26)

Fully angularly resolved 3D microrheology with optical tweezers (2024)
Journal Article

Microrheology with optical tweezers (MOT) is an all-optical technique that allows the user to investigate a materials’ viscoelastic properties at microscopic scales, and is particularly useful for those materials that feature complex microstructures,... Read More about Fully angularly resolved 3D microrheology with optical tweezers.

Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024)
Journal Article

Significance: Skin color affects light penetration leading to differences in its absorption and scattering properties. COVID-19 highlighted the importance of understanding of the interaction of light with different skin types, e.g., pulse oximetry (P... Read More about Effect of skin color on optical properties and the implications for medical optical technologies: a review.

Development of hydrogel-based standards and phantoms for non-linear imaging at depth (2023)
Journal Article

Significance: Rapid advances in medical imaging technology, particularly the development of optical systems with non-linear imaging modalities, are boosting deep tissue imaging. The development of reliable standards and phantoms is critical for valid... Read More about Development of hydrogel-based standards and phantoms for non-linear imaging at depth.

Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023)
Journal Article

Imaging non-invasively into the human body is currently limited by cost (MRI and CT scan), image resolution (ultrasound), exposure to ionising radiation (CT scan and X-ray), and the requirement for exogenous contrast agents (CT scan and PET scan). Op... Read More about Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited].

Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach (2023)
Journal Article

Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a minimally-invasive passive... Read More about Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.

OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures (2023)
Working Paper

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures.

C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance (2023)
Journal Article

In rheumatoid arthritis, the emergence of anti-citrullinated autoimmunity is associated with HLA-antigen-T cell receptor complexes. The precise mechanisms underpinning this breach of tolerance are not well understood. Porphyromonas gingivalis express... Read More about C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance.

Non-iterative aberration retrieval based on the spot shape around focus (2022)
Journal Article

A non-iterative, robust, aberration retrieval method to determine primary aberrations by utilizing the intensity distribution at and around focus is presented. The primary Zernike aberrations (coma, spherical aberration and astigmatism) are retrieved... Read More about Non-iterative aberration retrieval based on the spot shape around focus.

Ultra-compact and ultra-broadband hybrid plasmonic-photonic vertical coupler with high coupling efficiency, directivity, and polarisation extinction ratio (2022)
Journal Article

An ultra-compact, ultra-broadband vertical coupler for dense photonic integrated circuits is reported with a 1.07×0.62μm2 wavelength-scale footprint. This hybrid plasmonic-photonic coupler uses a unique two-plane plasmonic nanoantenna array on a sili... Read More about Ultra-compact and ultra-broadband hybrid plasmonic-photonic vertical coupler with high coupling efficiency, directivity, and polarisation extinction ratio.

Microrheology With an Anisotropic Optical Trap (2021)
Journal Article

Microrheology with optical tweezers (MOT) measurements are usually performed using optical traps that are close to isotropic across the plane being imaged, but little is known about what happens when this is not the case. In this work, we investigate... Read More about Microrheology With an Anisotropic Optical Trap.

Optical Tweezers with Integrated Multiplane Microscopy (OpTIMuM): a new tool for 3D microrheology (2021)
Journal Article

We introduce a novel 3D microrheology system that combines for the first time Optical Tweezers with Integrated Multiplane Microscopy (OpTIMuM). The system allows the 3D tracking of an optically trapped bead, with?~?20 nm accuracy along the optical ax... Read More about Optical Tweezers with Integrated Multiplane Microscopy (OpTIMuM): a new tool for 3D microrheology.

Microrheology reveals microscale viscosity gradients in planktonic systems (2020)
Journal Article

Microbial activity in planktonic systems creates a dynamic and heterogeneous microscale seascape that harbors a diverse community of microorganisms and ecological interactions of global significance. In recent decades great effort has been put into u... Read More about Microrheology reveals microscale viscosity gradients in planktonic systems.

Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells (2020)
Journal Article

© 2020 Author(s). Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad.... Read More about Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells.

Microrheology reveals microscale viscosity gradients in planktonic systems (2020)
Working Paper

Microbial activity in planktonic systems creates a dynamic and heterogeneous microscale seascape that harbours a diverse community of microorganisms and ecological interactions of global significance. In recent decades a great effort has been put int... Read More about Microrheology reveals microscale viscosity gradients in planktonic systems.

Detection of a common odd aberration in confocal reflection microscopy by means of an edge scan (2019)
Journal Article

In reflection laser scanning microscopes, detection of odd aberrations is challenging because aberration cancellation can occur after the second passage of the light beam through the system. A method is proposed that uses a sample containing high spa... Read More about Detection of a common odd aberration in confocal reflection microscopy by means of an edge scan.

Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro (2019)
Journal Article

© 2019 Current materials used for in vitro 3D cell culture are often limited by their poor similarity to human tissue, batch-to-batch variability and complexity of composition and manufacture. Here, we present a “blank slate” culture environment base... Read More about Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro.

Hybrid photonic-plasmonic platform for high-throughput single-molecule studies (2019)
Journal Article

We present the design and numerical characterization of a hybrid photonic-plasmonic nanoresonator comprised of a 2D photonic crystal (PhC) cavity, a gold bowtie nanoantenna (BNA) and a silicon dioxide, SiO2, spacer. This device is designed to serve a... Read More about Hybrid photonic-plasmonic platform for high-throughput single-molecule studies.

A minimally invasive optical trapping system to understand cellular interactions at onset of an immune response (2017)
Journal Article

T-cells and antigen presenting cells are an essential part of the adaptive immune response system and how they interact is crucial in how the body effectively fights infection or responds to vaccines. Much of the experimental work studying interactio... Read More about A minimally invasive optical trapping system to understand cellular interactions at onset of an immune response.