All Outputs (6)

Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer (2020)
Journal Article
Hedegaard, C. L., Redondo-Gómez, C., Tan, B. Y., Ng, K. W., Loessner, D., & Mata, A. (2020). Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer. Science Advances, 6(40), Article eabb3298. https://doi.org/10.1126/sciadv.abb3298

Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extrace... Read More about Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer.

Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels (2020)
Journal Article
Redondo-Gómez, C., Padilla-Lopategui, S., Azevedo, H. S., & Mata, A. (2020). Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels. ACS Biomaterials Science and Engineering, 6(9), 4870–4880. https://doi.org/10.1021/acsbiomaterials.0c00549

A key feature in biomaterial design is the incorporation of bioactive signals into artificial constructs to stimulate tissue regeneration. Most currently used hydrogel cell culture systems depend on the covalent attachment of extracellular matrix (EC... Read More about Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels.

Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures (2020)
Journal Article
Majkowska, A., Redondo-Gómez, C., Rice, A., Gonzalez, M., Inostroza-Brito, K. E., Collin, E., …Mata, A. (2020). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. Frontiers in Materials, 7, Article 167. https://doi.org/10.3389/fmats.2020.00167

Multicomponent self-assembly holds great promise for the generation of complex and functional biomaterials with hierarchical microstructure. Here, we describe the use of supramolecular co-assembly between an elastin-like recombinamer (ELR5) and a pep... Read More about Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures.

Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control (2020)
Journal Article
Hedegaard, C. L., & Mata, A. (2020). Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control. Biofabrication, 12(3), https://doi.org/10.1088/1758-5090/ab84cb

Nature has evolved to grow and regenerate tissues and organs using self-assembling processes capable of organizing a wide variety of molecular building-blocks at multiple size scales. As the field of biofabrication progresses, it is essential to deve... Read More about Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control.

Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro (2020)
Journal Article
Derkus, B., Okesola, B. O., Barrett, D. W., D'Este, M., Chowdhury, T. T., Eglin, D., & Mata, A. (2020). Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro. Acta Biomaterialia, 109, 82-94. https://doi.org/10.1016/j.actbio.2020.03.025

The native extracellular matrix (ECM) is a complex gel-like system with a broad range of structural features and biomolecular signals. Hydrogel platforms that can recapitulate the complexity and signaling properties of this ECM would have enormous im... Read More about Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro.

Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices (2020)
Journal Article
Wu, Y., Okesola, B. O., Xu, J., Korotkin, I., Berado, A., Corridori, I., …Mata, A. (2020). Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Communications, 11(1), Article 1182. https://doi.org/10.1038/s41467-020-14716-z

Supramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into functional materials and devices. Harnessing the inherent properties of... Read More about Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices.