Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing

Dhami, Sukhraj Pal S.; Kappala, Shanthi S.; Thompson, Alexander; Szegezdi, Eva

doi:10.1016/j.drudis.2016.04.019

All Outputs (2)

Low-dose salinomycin induces anti-leukemic responses in AML and MLL (2016)
Journal Article

Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are currently being used to identify candidates for repurposing based on their anti-cancer properties... Read More about Low-dose salinomycin induces anti-leukemic responses in AML and MLL.

Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing (2016)
Journal Article

Acute myeloid leukaemia (AML) is a hierarchically structured malignancy in which aberrant leukemic stem cells drive the production of leukaemic blast cell clones. AML cells strictly depend on the bone marrow microenvironment (BMM) in which they resid... Read More about Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.