All Outputs (4)

Low-dose salinomycin induces anti-leukemic responses in AML and MLL (2016)
Journal Article
Roulston, G. D., Burt, C. L., Kettyle, L. M., Matchett, K. B., Keenan, H. L., Mulgrew, N. M., …Thompson, A. (2016). Low-dose salinomycin induces anti-leukemic responses in AML and MLL. Oncotarget, https://doi.org/10.18632/oncotarget.11866

Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are currently being used to identify candidates for repurposing based on their anti-cancer properties... Read More about Low-dose salinomycin induces anti-leukemic responses in AML and MLL.

Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing (2016)
Journal Article
Dhami, S. P. S., Kappala, S. S., Thompson, A., & Szegezdi, E. (in press). Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing. Drug Discovery Today, 21(9), https://doi.org/10.1016/j.drudis.2016.04.019

Acute myeloid leukaemia (AML) is a hierarchically structured malignancy in which aberrant leukemic stem cells drive the production of leukaemic blast cell clones. AML cells strictly depend on the bone marrow microenvironment (BMM) in which they resid... Read More about Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.

Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells (2015)
Journal Article
Lebert-Ghali, C., Fournier, M., Kettyle, L. M., Thompson, A., Sauvageau, G., & Bijl, J. J. (2016). Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells. Blood, 127(1), 87-90. https://doi.org/10.1182/blood-2015-02-626390

Determination of defined roles for endogenous homeobox (Hox) genes in adult hematopoietic stem and progenitor cell (HSPC) activity has been hampered by a combination of embryonic defects and functional redundancy. Here we show that conditional homozy... Read More about Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer (2014)
Journal Article
Sharpe, D. J., Orr, K. S., Moran, M., White, S. J., McQuaid, S., Lappin, T. R., …James, J. A. (2014). POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer. Oncotarget, 5(18), https://doi.org/10.18632/oncotarget.2492

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous ce... Read More about POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.