All Outputs (89)

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II) (2019)
Journal Article
Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology, 58(8), 1378-1382. https://doi.org/10.1093/rheumatology/key446

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change.

Methods: Data from a clinical trial in which participants with ≥1 gout flare in th... Read More about Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II).

Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care (2018)
Journal Article
Latif, Z. P., Nakafero, G., Jenkins, W., Doherty, M., & Abhishek, A. (2019). Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care. Joint Bone Spine, 86(3), 357-362. https://doi.org/10.1016/j.jbspin.2018.10.008

Objectives To explore patient perception of the role of a nurse-led complex package of care in facilitating engagement with urate-lowering therapies (ULTs) in the management of gout.
Methods Thirty people who had participated in a randomised control... Read More about Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care.

Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial (2018)
Journal Article
Doherty, M., Jenkins, W., Richardson, H., Sarmanova, A., Abhishek, A., Ashton, D., …Zhang, W. (2018). Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial. Lancet, 392(10156), 1403-1412. https://doi.org/10.1016/S0140-6736%2818%2932158-5

Background: In the UK gout management is suboptimal, only 40% of patients receiving urate-lowering therapy (ULT), usually without titration to a target serum urate (SU) level. Nurses successfully manage many diseases in primary care. This trial compa... Read More about Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial.

Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative (2018)
Journal Article
Abhishek, A., Iagnocco, A., Bijlsma, J., Doherty, M., & Lioté, F. (2018). Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative. RMD Open, 4(2), Article e000743. https://doi.org/10.1136/rmdopen-2018-000743

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. Objectives To survey the undergraduate rheumatic and musculoskeletal diseases (RMDs) curriculum content in a sample of medical schools across Europe. Methods The... Read More about Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative.

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink (2018)
Journal Article
Pearce, F. A., Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., & Hubbard, R. B. (2018). Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink. Rheumatology, 57(10), 1873. https://doi.org/10.1093/rheumatology/key249

This is a correction to:
Rheumatology, Volume 57, Issue 6, June 2018, Pages 1002–1010, https://doi.org/10.1093/rheumatology/kex512

Correction to: The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink (2018)
Journal Article
Royle, J. G., Lanyon, P. C., Grainge, M. J., Abhishek, A., & Pearce, F. A. (2018). Correction to: The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink. Clinical Rheumatology, 37(9), 2601. https://doi.org/10.1007/s10067-018-4219-7

© 2018, International League of Associations for Rheumatology (ILAR). The above article originally published with an error present in the 2nd sentence in the 4th paragraph of the discussion section and is now presented correctly in this article. The... Read More about Correction to: The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., Chapman, V., Barrett, D. A., & Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), Article jlr.P085118. https://doi.org/10.1194/jlr.P085118

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink (2018)
Journal Article
Royle, J. G., Lanyon, P. C., Grainge, M. J., Abhishek, A., & Pearce, F. A. (2018). The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink. Clinical Rheumatology, 37(8), 2103–2111. https://doi.org/10.1007/s10067-018-4182-3

Objective: To estimate the incidence, prevalence and survival of systemic sclerosis in the United Kingdom.
Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence an... Read More about The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink.

The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink (2018)
Journal Article
Royle, J. G., Lanyon, P. C., Grainge, M. J., Abhishek, A., & Pearce, F. A. (2018). The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink. Clinical Rheumatology, 37(8), 2103-2111. https://doi.org/10.1007/s10067-018-4182-3

Abstract
To estimate the incidence, prevalence, and survival of systemic sclerosis in the United Kingdom. We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence and survival... Read More about The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink.

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P. R., Mallen, C., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., & Abhishek, A. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 57(10), 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives: To [1] examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK, [2] explore disease and demographic factors associated with vaccination.
Methods: 32,751 people with auto-immune rheumatic diseases (AIRDs) prescribed... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., Abhishek, A., Doherty, M., & Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study (2018)
Journal Article
Abhishek, A., Courtney, P., Jenkins, W., Sandoval-Plata, G., Jones, A., Zhang, W., & Doherty, M. (2018). Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis and Rheumatology, 70(11), 1847-1852. https://doi.org/10.1002/art.40572

Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout.

Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to t... Read More about Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study.

Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study (2018)
Journal Article
Fenton, S. A., Neogi, T., Dunlop, D., Nevitt, M., Doherty, M., Duda, J. L., …White, D. K. (2018). Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study. Osteoarthritis and Cartilage, 26(9), 1181-1189. https://doi.org/10.1016/j.joca.2018.04.015

Objective

Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear... Read More about Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study.

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink (2018)
Journal Article
Pearce, F. A., Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., & Hubbard, R. B. (2018). Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink. Rheumatology, 57(6), 1002-1010. https://doi.org/10.1093/rheumatology/kex512

Objectives:
We aimed to provide insights into the aetiology of granulomatosis with polyangiitis (GPA), by conducting a large case–control study using a general population-based, prospectively collected database of healthcare records.

Methods:
We... Read More about Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink.

Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink (2018)
Journal Article
Abhishek, A., Nakafero, G., Kuo, C.-F., Mallen, C., Zhang, W., Grainge, M. J., & Doherty, M. (2018). Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink. Rheumatology, 57(6), 977–981. https://doi.org/10.1093/rheumatology/key013

Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA.

Methods: Data from the Clinical Practice Research Datalink (CPRD) were used. Incident RA cases and four age, sex and general practice matched controls were id... Read More about Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink.

Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence (2017)
Journal Article
Kanavaki, A. M., Rushton, A., Efstathiou, N., Alrushud, A., Klocke, R., Abhishek, A., & Duda, J. L. (2017). Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence. BMJ Open, 7(12), Article e017042. https://doi.org/10.1136/bmjopen-2017-017042

Physical activity (PA), including engagement in structured exercise, has a key role in the management of hip and knee osteoarthritis (OA). However, maintaining a physically active lifestyle is a challenge for people with OA. PA determinants in this p... Read More about Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence.

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), Article e0186096. https://doi.org/10.1371/journal.pone.0186096

Objectives

To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More about Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study.

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study (2017)
Journal Article
Pearce, F. A., Hubbard, R. B., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (2018). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study. QJM: An International Journal of Medicine, 111(1), 39-45. https://doi.org/10.1093/qjmed/hcx194

© The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. Background: People with granulomatosis with polyangiitis (GPA) commonly described long delays before diagnosis. Aim: To study the... Read More about Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., Nessa, A., Williams, F. M., Spector, T. D., Doherty, M., Chapman, V., & Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room? (2017)
Journal Article
Abhishek, A., & Doherty, M. (2017). Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?. Arthritis Research and Therapy, 19, Article 184. https://doi.org/10.1186/s13075-017-1394-x

The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction... Read More about Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?.