Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans

Valdes, Ana M.; Ravipati, Srinivasarao; Menni, Cristina; Abhishek, Abhishek; Metrustry, Sarah; Harris, Juliette; Nessa, Ayrun; Williams, Frances M.K.; Spector, Tim D.; Doherty, Michael; Chapman, Victoria; Barrett, David A.

doi:10.1038/s41598-017-09516-3

All Outputs (8)

Upregulated expression of FFAR2 and SOC3 genes is associated with gout (2022)
Journal Article

Objective To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare. Methods Study... Read More about Upregulated expression of FFAR2 and SOC3 genes is associated with gout.

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank (2022)
Journal Article

Objective: To examine the association between common comorbidities, eGFR and loci involved in the hyperuricaemia-gout transition. Methods: This study was conducted in people with gout from the UK Biobank. Logistic regression was used to examine th... Read More about Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank.

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank (2021)
Journal Article

Objectives: To perform a genome-wide association study (GWAS) of gout cases vs. asymptomatic hyperuricaemia (AH) controls, and gout cases vs. normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case vs. AH-control... Read More about Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank (2020)
Journal Article

Objectives To examine the association between comorbidities and serum urate (SU), gout and comorbidities, and to determine whether the association between gout and comorbidities is independent of SU. Methods We performed a case-control study using UK... Read More about Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.