Angela Heinrich
Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity
Heinrich, Angela; M�ller, Kathrin U.; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; B�chel, Christian; Conrod, Patricia; Fauth-B�hler, Mira; Papadopoulos, Dimitri; Gallinat, J�rgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Paus, Tom�; Pausova, Zdenka; Smolka, Michael; Str�hle, Andreas; Rietschel, Marcella; Flor, Herta; Schumann, Gunter; Nees, Frauke
Authors
Kathrin U. M�ller
Tobias Banaschewski
Gareth J. Barker
Arun L.W. Bokde
Uli Bromberg
Christian B�chel
Patricia Conrod
Mira Fauth-B�hler
Dimitri Papadopoulos
J�rgen Gallinat
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Karl Mann
Jean-Luc Martinot
Tom� Paus
Zdenka Pausova
Michael Smolka
Andreas Str�hle
Marcella Rietschel
Herta Flor
Gunter Schumann
Frauke Nees
Abstract
Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced.
Citation
Heinrich, A., Müller, K. U., Banaschewski, T., Barker, G. J., Bokde, A. L., Bromberg, U., …Nees, F. (2016). Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity. Biological Psychology, 118, https://doi.org/10.1016/j.biopsycho.2016.05.002
Journal Article Type | Article |
---|---|
Acceptance Date | May 11, 2016 |
Online Publication Date | May 12, 2016 |
Publication Date | Jul 1, 2016 |
Deposit Date | May 9, 2017 |
Journal | Biological Psychology |
Print ISSN | 0301-0511 |
Electronic ISSN | 1873-6246 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 118 |
DOI | https://doi.org/10.1016/j.biopsycho.2016.05.002 |
Keywords | Prediction of alcohol consumption; Adolescents; Longitudinal study; Personality; Behavior; Brain responses; Genetic variations |
Public URL | https://nottingham-repository.worktribe.com/output/975968 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S0301051116301818 |
Contract Date | May 9, 2017 |
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