@article { , title = {Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity}, abstract = {Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced.}, doi = {10.1016/j.biopsycho.2016.05.002}, eissn = {1873-6246}, issn = {0301-0511}, journal = {Biological Psychology}, note = {AAM needed with CCANCND. TJJ 10.05.17}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://nottingham-repository.worktribe.com/output/975968}, volume = {118}, keyword = {Prediction of alcohol consumption, Adolescents, Longitudinal study, Personality, Behavior, Brain responses, Genetic variations}, year = {2016}, author = {Heinrich, Angela and Müller, Kathrin U. and Banaschewski, Tobias and Barker, Gareth J. and Bokde, Arun L.W. and Bromberg, Uli and Büchel, Christian and Conrod, Patricia and Fauth-Bühler, Mira and Papadopoulos, Dimitri and Gallinat, Jürgen and Garavan, Hugh and Gowland, Penny and Heinz, Andreas and Ittermann, Bernd and Mann, Karl and Martinot, Jean-Luc and Paus, Tomáš and Pausova, Zdenka and Smolka, Michael and Ströhle, Andreas and Rietschel, Marcella and Flor, Herta and Schumann, Gunter and Nees, Frauke} }