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Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity

Authors

Angela Heinrich

Kathrin U.

Tobias Banaschewski

Gareth J. Barker

Arun L.W. Bokde

Uli Bromberg

Christian

Patricia Conrod

Mira

Dimitri Papadopoulos

Gallinat

Hugh Garavan

Andreas Heinz

Bernd Ittermann

Karl Mann

Jean-Luc Martinot

Paus

Zdenka Pausova

Michael Smolka

Andreas

Marcella Rietschel

Herta Flor

Gunter Schumann

Frauke Nees



Abstract

Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced.

Citation

Heinrich, A., Müller, K. U., Banaschewski, T., Barker, G. J., Bokde, A. L., Bromberg, U., …Nees, F. (2016). Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity. Biological Psychology, 118, https://doi.org/10.1016/j.biopsycho.2016.05.002

Journal Article Type Article
Acceptance Date May 11, 2016
Online Publication Date May 12, 2016
Publication Date Jul 1, 2016
Deposit Date May 9, 2017
Journal Biological Psychology
Print ISSN 0301-0511
Electronic ISSN 1873-6246
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 118
DOI https://doi.org/10.1016/j.biopsycho.2016.05.002
Keywords Prediction of alcohol consumption; Adolescents; Longitudinal study; Personality; Behavior; Brain responses; Genetic variations
Public URL https://nottingham-repository.worktribe.com/output/975968
Publisher URL http://www.sciencedirect.com/science/article/pii/S0301051116301818