Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India

Hemadri, D.; Maan, Sushila; Rao, Prarthana Nagaraj; Putty, Kalyani; Krishnajyothi, Yadlapati; Reddy, G. Hanmanth; Kumar, Vinay; Batra, Kanisht; Reddy, Y. Vishnuvardhan; Maan, Narender Singh; Reddy, Yella Narasimha; Singh, Karam Pal; Shivachandra, Sathish Bhadravati; Hegde, Nagendra; Rahman, Habibur; Mertens, Peter P.C.

Abstract

Bluetongue is endemic in India and has been reported from most Indian states. Of late, the clinical disease is most frequently seen in the states of Andhra Pradesh, Telangana (erstwhile Andhra Pradesh state), Tamil Nadu and Karnataka. Our analysis of diagnostic samples from bluetongue outbreaks during 2010–2011 from the state of Karnataka identified bluetongue virus (BTV) serotype 5 (BTV-5) for the first time in India. One of the diagnostic samples (CH1) and subsequent virus isolate (IND2010/02) contained both BTV-2 and BTV-5. Segment 2 (seg-2) sequence data (400 bp: nucleotides 2538–2921) for IND2010/02-BTV5, showed 94.3% nucleotide identity to BTV-5 from South Africa (Accession no. AJ585126), confirming the virus serotype and also indicating that Seg-2 was derived from a Western topotype, which is in contrast to serotype 2, that belongs to an Eastern topotype. BTV-5 has been recently reported from Africa, China, French islands and the Americas. Although the exact source of the Indian BTV-5 isolate is still to be confirmed, recent identification of additional exotic serotypes in India is of real concern and might add to the severity of the disease seen in these outbreaks.

Citation

Hemadri, D., Maan, S., Rao, P. N., Putty, K., Krishnajyothi, Y., Reddy, G. H., …Mertens, P. P. (2017). Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India. Transboundary and Emerging Diseases, 64(6), 1912-1917. https://doi.org/10.1111/tbed.12589

• Journal Article Type: Article
• Acceptance Date: Dec 21, 2016
• Online Publication Date: Dec 21, 2016
• Publication Date: Dec 1, 2017
• Deposit Date: Feb 9, 2017
• Publicly Available Date: Feb 9, 2017
• Journal: Transboundary and Emerging Diseases
• Print ISSN: 1865-1674
• Electronic ISSN: 1865-1682
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 6
• Pages: 1912-1917
• DOI: https://doi.org/10.1111/tbed.12589
• Keywords: bluetongue; serotype 5; India; topotype
• Public URL: https://nottingham-repository.worktribe.com/output/964507
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/tbed.12589/abstract
• Additional Information: This is the peer reviewed version of the following article: Hemadri, D., Maan, S., Chanda, M. M., Rao, P. P., Putty, K., Krishnajyothi, Y., Reddy, G. H., Kumar, V., Batra, K., Reddy, Y. V., Maan, N. S., Reddy, Y. N., Singh, K. P., Shivachandra, S. B., Hegde, N. R., Rahman, H. and Mertens, P. P. C. (2016), Dual Infection with Bluetongue Virus Serotypes and First-Time Isolation of Serotype 5 in India. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12589, which has been published in final form at http://dx.doi.org/10.1111/tbed.12589. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.