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Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort

Brookes, Keeley J.; McConnell, G.; Williams, K.; Chaudhury, Sultan R; Madhan, G.; Patel, T.; Turley, C.; Guetta-Baranes, Tamar; Francis, Paul T.; Morgan, Kevin

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Authors

Keeley J. Brookes

G. McConnell

K. Williams

Sultan R Chaudhury

G. Madhan

T. Patel

C. Turley

Tamar Guetta-Baranes

Paul T. Francis

Kevin Morgan



Abstract

The Brains for Dementia Research project is a recently established cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ε4 allele was identified (P=3.99x10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al GWAS meta-analysis was observed.

Citation

Brookes, K. J., McConnell, G., Williams, K., Chaudhury, S. R., Madhan, G., Patel, T., …Morgan, K. (2018). Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort. Journal of Alzheimer's Disease, 64(2), https://doi.org/10.3233/JAD-180191

Journal Article Type Article
Acceptance Date May 1, 2018
Publication Date Jun 19, 2018
Deposit Date May 2, 2018
Publicly Available Date Mar 29, 2024
Journal Journal of Alzheimer's Disease
Print ISSN 1387-2877
Electronic ISSN 1387-2877
Publisher IOS Press
Peer Reviewed Peer Reviewed
Volume 64
Issue 2
DOI https://doi.org/10.3233/JAD-180191
Keywords Alzheimer’s disease, association, Brains for Dementia Research, genome-wide association study, single nucleotide polymorphisms
Public URL https://nottingham-repository.worktribe.com/output/939150
Publisher URL https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180191

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