Skip to main content

Research Repository

Advanced Search

Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging

Bradley, Christopher R.; Cox, Eleanor F.; Scott, Robert A.; James, Martin W.; Kaye, Philip; Aithal, Guruprasad P.; Francis, Susan T.; Guha, Indra Neil

Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging Thumbnail


Authors

ELEANOR COX ELEANOR.COX@NOTTINGHAM.AC.UK
Senior Research Fellow

Robert A. Scott

Martin W. James

Philip Kaye

Profile Image

NEIL GUHA neil.guha@nottingham.ac.uk
Professor of Hepatology



Abstract

© 2018 European Association for the Study of the Liver Background & Aims: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the balance of benefit vs. harm for therapies. Our aim was to establish the feasibility of magnetic resonance imaging (MRI) to assess changes in Compensated Cirrhosis (CC), and relate this to disease severity and future liver-related outcomes (LROs). Methods: A total of 60 patients with CC, 40 healthy volunteers and 7 patients with decompensated cirrhosis were recruited. In a single scan session, MRI measures comprised phase-contrast MRI vessel blood flow, arterial spin labelling tissue perfusion, T1 longitudinal relaxation time, heart rate, cardiac index, and volume assessment of the liver, spleen and kidneys. We explored the association between MRI parameters and disease severity, analysing differences in baseline MRI parameters in the 11 (18%) patients with CC who experienced future LROs. Results: In the liver, compositional changes were reflected by increased T1 in progressive disease (p

Citation

Bradley, C. R., Cox, E. F., Scott, R. A., James, M. W., Kaye, P., Aithal, G. P., …Guha, I. N. (2018). Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. Journal of Hepatology, 69(5), 1015-1024. https://doi.org/10.1016/j.jhep.2018.05.037

Journal Article Type Article
Acceptance Date May 30, 2018
Online Publication Date Jun 8, 2018
Publication Date Nov 1, 2018
Deposit Date Jun 26, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Hepatology
Print ISSN 0168-8278
Electronic ISSN 1600-0641
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 69
Issue 5
Pages 1015-1024
DOI https://doi.org/10.1016/j.jhep.2018.05.037
Keywords Compensated Cirrhosis, Magnetic Resonance Imaging, Arterial Spin Labelling, Phase Contrast, Longitudinal T1 relaxation time.
Public URL https://nottingham-repository.worktribe.com/output/936920
Publisher URL https://www.sciencedirect.com/science/article/pii/S0168827818321226
Additional Information This article is maintained by: Elsevier; Article Title: Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging; Journal Title: Journal of Hepatology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jhep.2018.05.037; Content Type: article; Copyright: © 2018 European Association for the Study of the Liver. Published by Elsevier B.V.

Files





You might also like



Downloadable Citations