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Nucleoside based self-assembling drugs for localized drug delivery

Skilling, Kathryn J.; Stocks, Michael J.; Kellam, Barrie; Ashford, Marianne; Bradshaw, Tracey; Burroughs, Laurence; Marlow, Maria

Authors

Kathryn J. Skilling

Michael J. Stocks Michael.Stocks@nottingham.ac.uk

Barrie Kellam

Marianne Ashford

Tracey Bradshaw

Laurence Burroughs

Maria Marlow



Abstract

We have synthesized a range of gelators based on nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and TEM. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside based gelators for localized drug delivery.

Journal Article Type Article
Journal ChemMedChem
Print ISSN 1860-7179
Electronic ISSN 1860-7179
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Skilling, K. J., Stocks, M. J., Kellam, B., Ashford, M., Bradshaw, T., Burroughs, L., & Marlow, M. (in press). Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem, doi:10.1002/cmdc.201800063
DOI https://doi.org/10.1002/cmdc.201800063
Keywords drug delivery ; gels ; gemcitabine ; lamivudine ; nucleosides
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800063
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer-reviewed version of the following article, which has been published in final form at https://onlinelibrary.w...10.1002/cmdc.201800063. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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