Nucleoside based self-assembling drugs for localized drug delivery

Skilling, Kathryn J.; Stocks, Michael J.; Kellam, Barrie; Ashford, Marianne; Bradshaw, Tracey; Burroughs, Laurence; Marlow, Maria

Abstract

We have synthesized a range of gelators based on nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and TEM. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside based gelators for localized drug delivery.

Citation

Skilling, K. J., Stocks, M. J., Kellam, B., Ashford, M., Bradshaw, T., Burroughs, L., & Marlow, M. (in press). Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem, https://doi.org/10.1002/cmdc.201800063

• Journal Article Type: Article
• Acceptance Date: Mar 20, 2018
• Online Publication Date: May 2, 2018
• Deposit Date: May 3, 2018
• Publicly Available Date: May 3, 2019
• Journal: ChemMedChem
• Print ISSN: 1860-7179
• Electronic ISSN: 1860-7179
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/cmdc.201800063
• Keywords: drug delivery ; gels ; gemcitabine ; lamivudine ; nucleosides
• Public URL: https://nottingham-repository.worktribe.com/output/930416
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800063
• Additional Information: This is the peer-reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201800063. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.