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Nucleoside based self-assembling drugs for localized drug delivery

Skilling, Kathryn J.; Stocks, Michael J.; Kellam, Barrie; Ashford, Marianne; Bradshaw, Tracey; Burroughs, Laurence; Marlow, Maria


Kathryn J. Skilling

Professor of Medicinal Chemistry and Drug Discovery

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Professor of Medicinal Chemistry

Marianne Ashford

Laurence Burroughs


We have synthesized a range of gelators based on nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and TEM. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside based gelators for localized drug delivery.


Skilling, K. J., Stocks, M. J., Kellam, B., Ashford, M., Bradshaw, T., Burroughs, L., & Marlow, M. (in press). Nucleoside based self-assembling drugs for localized drug delivery. ChemMedChem,

Journal Article Type Article
Acceptance Date Mar 20, 2018
Online Publication Date May 2, 2018
Deposit Date May 3, 2018
Publicly Available Date May 3, 2019
Journal ChemMedChem
Print ISSN 1860-7179
Electronic ISSN 1860-7179
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords drug delivery ; gels ; gemcitabine ; lamivudine ; nucleosides
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Additional Information This is the peer-reviewed version of the following article, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.


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