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Garlic and gaseous mediators

Rose, Peter; Moore, Philip Keith; Zhu, Yi-Zhun

Authors

PETER ROSE Peter.Rose@nottingham.ac.uk
Assistant Professor

Philip Keith Moore

Yi-Zhun Zhu



Abstract

Garlic (Allium sativum) and allied plant species are rich sources of sulfur compounds. Major roles for garlic and its sulfur constituents include the regulation of vascular homeostasis and the control of metabolic systems linked to nutrient metabolism. Recent studies have indicated that some of these sulfur compounds, such as diallyl trisulfide (DATS), alter the levels of gaseous signalling molecules including nitric oxide (NO), hydrogen sulfide (H2S), and perhaps carbon monoxide (CO) in mammalian tissues. These gases are important in cellular processes associated with the cardiovascular system, inflammation, and neurological functions. Importantly, these studies build on the known biological effects of garlic and associated sulfur constituents. This review highlights our current understanding of the health benefits attributed to edible plants like garlic.

Citation

Rose, P., Moore, P. K., & Zhu, Y. (in press). Garlic and gaseous mediators. Trends in Pharmacological Sciences, https://doi.org/10.1016/j.tips.2018.03.009

Journal Article Type Article
Acceptance Date Mar 26, 2018
Online Publication Date Apr 26, 2018
Deposit Date May 22, 2018
Publicly Available Date Mar 28, 2024
Journal Trends in Pharmacological Sciences
Print ISSN 0165-6147
Electronic ISSN 1873-3735
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1016/j.tips.2018.03.009
Keywords Hydrogen sulfide; Nitric oxide; Carbon monoxide; Gaseous mediators; Garlic; Polysulfide
Public URL https://nottingham-repository.worktribe.com/output/928783
Publisher URL https://doi.org/10.1016/j.tips.2018.03.009