Garlic and gaseous mediators

Rose, Peter; Moore, Philip Keith; Zhu, Yi-Zhun

Abstract

Garlic (Allium sativum) and allied plant species are rich sources of sulfur compounds. Major roles for garlic and its sulfur constituents include the regulation of vascular homeostasis and the control of metabolic systems linked to nutrient metabolism. Recent studies have indicated that some of these sulfur compounds, such as diallyl trisulfide (DATS), alter the levels of gaseous signalling molecules including nitric oxide (NO), hydrogen sulfide (H2S), and perhaps carbon monoxide (CO) in mammalian tissues. These gases are important in cellular processes associated with the cardiovascular system, inflammation, and neurological functions. Importantly, these studies build on the known biological effects of garlic and associated sulfur constituents. This review highlights our current understanding of the health benefits attributed to edible plants like garlic.

Citation

Rose, P., Moore, P. K., & Zhu, Y.-Z. (in press). Garlic and gaseous mediators. Trends in Pharmacological Sciences, https://doi.org/10.1016/j.tips.2018.03.009

• Journal Article Type: Article
• Acceptance Date: Mar 26, 2018
• Online Publication Date: Apr 26, 2018
• Deposit Date: May 22, 2018
• Journal: Trends in Pharmacological Sciences
• Print ISSN: 0165-6147
• Electronic ISSN: 1873-3735
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.tips.2018.03.009
• Keywords: Hydrogen sulfide; Nitric oxide; Carbon monoxide; Gaseous mediators; Garlic; Polysulfide
• Public URL: https://nottingham-repository.worktribe.com/output/928783
• Publisher URL: https://doi.org/10.1016/j.tips.2018.03.009
• Contract Date: May 22, 2018