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Water contact angle is not a good predictor of biological responses to materials

Alexander, Morgan R.; Williams, Paul

Authors

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MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces

PAUL WILLIAMS PAUL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Molecular Microbiology



Abstract

Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions.

Citation

Alexander, M. R., & Williams, P. (in press). Water contact angle is not a good predictor of biological responses to materials. Biointerphases, 12(2), Article 02C201. https://doi.org/10.1116/1.4989843

Journal Article Type Article
Acceptance Date Jun 8, 2017
Online Publication Date Jul 6, 2017
Deposit Date Dec 6, 2017
Publicly Available Date Mar 29, 2024
Journal Biointerphases
Print ISSN 1934-8630
Electronic ISSN 1934-8630
Publisher American Institute of Physics
Peer Reviewed Peer Reviewed
Volume 12
Issue 2
Article Number 02C201
DOI https://doi.org/10.1116/1.4989843
Public URL https://nottingham-repository.worktribe.com/output/871739
Publisher URL http://avs.scitation.org/doi/abs/10.1116/1.4989843