Peroxisome proliferator-activated receptor ? agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats

Crossland, Hannah; Constantin-Teodosiu, Dumitru; Gardiner, Sheila M.; Greenhaff, PaulL.

Abstract

The peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone (Rosi) appears to provide protection against organ dysfunction during endotoxaemia. We examined the potential benefits of Rosi on skeletal muscle protein maintenance and carbohydrate metabolism during lipopolysaccharide (LPS)-induced endotoxaemia. Sprague-Dawley rats were fed either standard chow (control) or standard chow containing Rosi (8.5±0.1 mg.kg-1.day-1) for two weeks before and during 24 h continuous intravenous infusion of LPS (15 μg.kg-1.h-1) or saline. Rosi blunted LPS-induced increases in muscle tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) mRNA by 70% (P

• Journal Article Type: Article
• Acceptance Date: May 23, 2017
• Online Publication Date: May 23, 2017
• Publication Date: Jul 1, 2017
• Deposit Date: Jul 17, 2017
• Publicly Available Date: Jul 17, 2017
• Journal: Clinical Science
• Print ISSN: 0143-5221
• Electronic ISSN: 1470-8736
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 131
• Issue: 13
• Pages: 1437-1447
• DOI: https://doi.org/10.1042/CS20170958
• Keywords: sepsis, inflammation, muscle atrophy, muscle insulin resistance
• Public URL: https://nottingham-repository.worktribe.com/output/867524
• Publisher URL: http://www.clinsci.org/content/131/13/1437