Khalid A. Jadoon
A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
Jadoon, Khalid A.; Tan, Garry D.; O'Sullivan, Saoirse
Authors
Garry D. Tan
Saoirse O'Sullivan
Abstract
BACKGROUND. Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim of this study was to investigate if CBD reduces BP in humans.
METHODS. Nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-controlled, double-blind, crossover study. Cardiovascular parameters were monitored using a finometer and laser Doppler.
RESULTS. CBD reduced resting systolic BP (–6 mmHg; P < 0.05) and stroke volume (–8 ml; P < 0.05), with increased heart rate (HR) and maintained cardiac output. Subjects who had taken CBD had lower BP (–5 mmHg; P < 0.05, especially before and after stress), increased HR (+10 bpm; P < 0.01), decreased stroke volume (–13 ml; P < 0.01), and a blunted forearm skin blood flow response to isometric exercise. In response to cold stress, subjects who had taken CBD had blunted BP (–6 mmHg; P < 0.01) and increased HR (+7 bpm; P < 0.05), with lower total peripheral resistance.
CONCLUSIONS. This data shows that acute administration of CBD reduces resting BP and the BP increase to stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.
Citation
Jadoon, K. A., Tan, G. D., & O'Sullivan, S. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI insight, 2(11), Article e93760. https://doi.org/10.1172/jci.insight.93760
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 27, 2017 |
Publication Date | Jun 15, 2017 |
Deposit Date | Jun 30, 2017 |
Publicly Available Date | Jun 30, 2017 |
Journal | JCI Insight |
Electronic ISSN | 2379-3708 |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 11 |
Article Number | e93760 |
DOI | https://doi.org/10.1172/jci.insight.93760 |
Public URL | https://nottingham-repository.worktribe.com/output/865923 |
Publisher URL | https://insight.jci.org/articles/view/93760 |
Related Public URLs | http://insight.jci.org |
Files
render O'Sullivan.pdf
(1.2 Mb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search