SARAH STORR sarah.storr@nottingham.ac.uk
Assistant Professor
Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro
Storr, Sarah J.; Safuan, Sabreena; Ahmad, Narmeen; El-Refaee, Mohammed; Jackson, Andrew M.; Martin, Stewart G.
Authors
Sabreena Safuan
Narmeen Ahmad
Mohammed El-Refaee
ANDREW JACKSON ANDREW.JACKSON@NOTTINGHAM.AC.UK
Associate Professor
STEWART MARTIN STEWART.MARTIN@NOTTINGHAM.AC.UK
Professor of Cancer and Radiation Biology
Abstract
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1 dependent interleukin-1beta (IL-1?) in an in vitro model of LVI.
IL-1? significantly augmented the adhesion and transmigration of breast cancer cell lines MCF7 and MDA-MB-231 across endothelial cell barriers. MDA-MB-231 and MCF7 showed a higher percentage of adhesion to lymphatic endothelial cells than blood endothelial cells following endothelial cell IL-1? stimulation (P
Citation
Storr, S. J., Safuan, S., Ahmad, N., El-Refaee, M., Jackson, A. M., & Martin, S. G. (2017). Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro. Cancer Immunology, Immunotherapy, 66(10), 1287-1294. https://doi.org/10.1007/s00262-017-2020-0
Journal Article Type | Article |
---|---|
Acceptance Date | May 20, 2017 |
Online Publication Date | May 27, 2017 |
Publication Date | 2017-10 |
Deposit Date | May 25, 2017 |
Publicly Available Date | May 27, 2017 |
Journal | Cancer Immunology, Immunotherapy |
Print ISSN | 0340-7004 |
Electronic ISSN | 1432-0851 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 66 |
Issue | 10 |
Pages | 1287-1294 |
DOI | https://doi.org/10.1007/s00262-017-2020-0 |
Keywords | interleukin-1; breast cancer; macrophage; vascular invasion; caspase-1 |
Public URL | https://nottingham-repository.worktribe.com/output/862235 |
Publisher URL | https://link.springer.com/article/10.1007%2Fs00262-017-2020-0 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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