@article { , title = {Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro}, abstract = {Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1 dependent interleukin-1beta (IL-1?) in an in vitro model of LVI. IL-1? significantly augmented the adhesion and transmigration of breast cancer cell lines MCF7 and MDA-MB-231 across endothelial cell barriers. MDA-MB-231 and MCF7 showed a higher percentage of adhesion to lymphatic endothelial cells than blood endothelial cells following endothelial cell IL-1? stimulation (P}, doi = {10.1007/s00262-017-2020-0}, eissn = {1432-0851}, issn = {0340-7004}, issue = {10}, journal = {Cancer Immunology, Immunotherapy}, pages = {1287-1294}, publicationstatus = {Published}, publisher = {Springer Verlag}, url = {https://nottingham-repository.worktribe.com/output/862235}, volume = {66}, keyword = {interleukin-1, breast cancer, macrophage, vascular invasion, caspase-1}, year = {2017}, author = {Storr, Sarah J. and Safuan, Sabreena and Ahmad, Narmeen and El-Refaee, Mohammed and Jackson, Andrew M. and Martin, Stewart G.} }