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Evolution of complexity in the zebrafish synapse proteome

Bayés, Àlex; Bayes, Alex; Collins, Mark O.; Reig-Vader, Rrita; Gou, Gemma; Goulding, David; Izquierdo, Abril; Choudhary, Jyoti S.; Emes, Richard D.; Grant, Seth G.N.

Authors

Àlex Bayés

Alex Bayes

Mark O. Collins

Rrita Reig-Vader

Gemma Gou

David Goulding

Abril Izquierdo

Jyoti S. Choudhary

RICHARD EMES richard.emes@nottingham.ac.uk
Professor of Bioinformatics

Seth G.N. Grant



Abstract

The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases, however its synapse proteome is uncharacterised and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. We report the characterisation of the proteomes and ultrastructure of central synapses in zebrafish and analyse the importance of the TSGD. While the TSGD increases overall synapse proteome complexity, the Post Synaptic Density (PSD) proteome of zebrafish has lower complexity than mammals. A highly conserved set of ~1000 proteins is shared across vertebrates. PSD ultrastructural features are also conserved. Lineage-specific proteome differences indicate vertebrate species evolved distinct synapse types and functions. The datasets are a resource for a wide range of studies and have important implications for the use of zebrafish in modelling human synaptic diseases.

Journal Article Type Article
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 8
Article Number 14613
APA6 Citation Bayés, À., Bayes, A., Collins, M. O., Reig-Vader, R., Gou, G., Goulding, D., …Grant, S. G. (in press). Evolution of complexity in the zebrafish synapse proteome. Nature Communications, 8, https://doi.org/10.1038/ncomms14613
DOI https://doi.org/10.1038/ncomms14613
Publisher URL http://www.nature.com/articles/ncomms14613
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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