Hilda Amekyeh
Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry
Amekyeh, Hilda; Billa, Nashiru; Roberts, Clive J.
Authors
Abstract
Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used as carriers to improve the absorption of hydrophobic drugs. In this study, we examine the stability of amphotericin B (AmB) and paracetamol (PAR) SLNs in simulated GI fluids during gastric emptying. On contact with the simulated fluids, the particles increased in size due to ingress of the dissolution media into the particles. Simulated gastric emptying revealed that the formulations had mean sizes <350 nm and neutral surface charges, both of which are optimal for intestinal absorption of SLNs. There was ingress of the fluids into the SLNs, followed by diffusion of the dissolved drug, whose rate depended on the solubility of the loaded-drug in the particular medium. Time-of-flight secondary ion mass spectrometry analyses indicated that drug loading followed the core-shell model and that the AmB SLNs have a more drug-enriched core than the PAR SLNs do. The AmB SLNs are therefore a very suitable carrier of AmB for oral delivery. The stability of the SLNs in the simulated GI media indicates their suitability for oral delivery.
Citation
Amekyeh, H., Billa, N., & Roberts, C. J. (2017). Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry. International Journal of Pharmaceutics, 517(1-2), https://doi.org/10.1016/j.ijpharm.2016.12.001
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 1, 2016 |
Online Publication Date | Dec 5, 2016 |
Publication Date | Jan 30, 2017 |
Deposit Date | May 23, 2017 |
Publicly Available Date | May 23, 2017 |
Journal | International Journal of Pharmaceutics |
Print ISSN | 0378-5173 |
Electronic ISSN | 1873-3476 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 517 |
Issue | 1-2 |
DOI | https://doi.org/10.1016/j.ijpharm.2016.12.001 |
Keywords | Solid lipid nanoparticle; Stability; Gastrointestinal tract; Gastric emptying; Amphotericin B; Paracetamol |
Public URL | https://nottingham-repository.worktribe.com/output/838552 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S0378517316311322 |
Contract Date | May 23, 2017 |
Files
Ampho Surface Chem (International Journal of P) for repository.pdf
(791 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
You might also like
Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites
(2022)
Preprint / Working Paper
Utilising micron scale 3D printed morphologies for particle adhesion reduction
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search