Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues

Marsit, Nagi M.; Sidney, Laura E.; Branch, Matthew James; Wilson, Samantha L.; Hopkinson, Andrew

Abstract

Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well-established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.

Citation

Marsit, N. M., Sidney, L. E., Branch, M. J., Wilson, S. L., & Hopkinson, A. (in press). Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues. Plasma Processes and Polymers, https://doi.org/10.1002/ppap.201600134

• Journal Article Type: Article
• Acceptance Date: Nov 13, 2016
• Online Publication Date: Dec 15, 2016
• Deposit Date: Jan 17, 2017
• Publicly Available Date: Jan 17, 2017
• Journal: Plasma Processes and Polymers
• Print ISSN: 1612-8850
• Electronic ISSN: 1612-8869
• Publisher: Wiley-VCH Verlag
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/ppap.201600134
• Keywords: Cold plasma; Dielectric barrier discharge; Plasma treatment; Sterilization; Tissue engineering
• Public URL: https://nottingham-repository.worktribe.com/output/833337
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/ppap.201600134/abstract
• Additional Information: This is the accepted version of the following article: Marsit NM, Sidney LE, Branch MJ, Wilson SL, and Hopkinson A. Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues. Plasma Process Polym. 2016; 9999:e201600134. doi:10.1002/ppap.201600134 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppap.201600134/abstract . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy.
• Contract Date: Jan 17, 2017