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Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders

Beeken, Lydia J.; Ting, Darren S. J.; Sidney, Laura E.

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Authors

Lydia J. Beeken

Darren S. J. Ting

LAURA SIDNEY LAURA.SIDNEY@NOTTINGHAM.AC.UK
Senior Research Fellow



Abstract

Ocular surface inflammatory disorders (OSIDs) are a group of highly prevalent, heterogeneous diseases which display a variety of aetiologies and symptoms and are risk factors for serious complications including ocular and cornea impairment. Corneal inflammation is a common factor of all OSIDs, regardless of their cause or symptoms. Current medications include over?the?counter lubricating eye drops, corticosteroids, and ciclosporin, which either do not treat the corneal inflammation or have been associated with multiple side effects leading to alternative treatments being sought. Regenerative medicine cell therapies, particularly mesenchymal stem cells (MSCs), have shown great promise for immunosuppression and disease amelioration across multiple tissues, including the cornea. However, for successful development and clinical translation of MSC therapy for OSIDs, significant problems must be addressed. This review aims to highlight considerations, including whether the source of MSC isolation impacts the efficacy and safety of the therapy, in addition to assessing the feasibility of MSC topical application to the cornea and ocular surface through analysis of potential scaffolds and cell carriers for application to the eye. The literature contains limited data assessing MSCs incorporated into scaffolds for corneal administration, thus here we highlight the necessity of further investigations to truly exploit the potential of an MSC?based cell therapy for the treatment of OSIDs.

Journal Article Type Article
Acceptance Date Jul 30, 2020
Online Publication Date Sep 8, 2020
Publication Date Dec 29, 2020
Deposit Date Sep 23, 2020
Publicly Available Date Sep 23, 2020
Journal Stem Cells Translational Medicine
Print ISSN 2157-6564
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Pages 39-49
DOI https://doi.org/10.1002/sctm.20-0118
Keywords Developmental Biology; Cell Biology; General Medicine
Public URL https://nottingham-repository.worktribe.com/output/4921620
Publisher URL https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0118

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