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Preparation of Dried Amniotic Membrane for Corneal Repair

Hopkinson, Andrew; Britchford, Emily R.; Sidney, Laura E.

Authors

Andrew Hopkinson

Emily R. Britchford

LAURA SIDNEY LAURA.SIDNEY@NOTTINGHAM.AC.UK
Senior Research Fellow



Contributors

Mark Ahearne
Editor

Abstract

Amniotic membrane transplantation is an established therapeutic and biological adjunct for several clinical situations, including treatment of diabetic foot ulcers and ocular surface disease. However, poorly standardized and validated clinical preparation and storage procedures can render the final product highly variable and an unpredictable biomaterial. We have therefore developed a novel, standardized method for processing and dry-preserving amniotic membrane, minimizing biochemical, compositional, and structure damage to produce a potentially superior membrane suitable for clinical use. The intellectual property associated with this methodology was patented by the University of Nottingham and licensed to NuVision® Biotherapies which formed the basis of the Tereo® manufacturing process which is used to manufacture Omnigen®.

Citation

Hopkinson, A., Britchford, E. R., & Sidney, L. E. (2020). Preparation of Dried Amniotic Membrane for Corneal Repair. In M. Ahearne (Ed.), Corneal Regeneration: Methods and Protocols (143-157). Springer US. https://doi.org/10.1007/978-1-0716-0599-8_10

Online Publication Date Jun 16, 2020
Publication Date Jun 16, 2020
Deposit Date Jul 14, 2020
Pages 143-157
Series Title Methods in Molecular Biology
Series Number 2145
Book Title Corneal Regeneration: Methods and Protocols
ISBN 9781071605981
DOI https://doi.org/10.1007/978-1-0716-0599-8_10
Public URL https://nottingham-repository.worktribe.com/output/4767294
Publisher URL https://link.springer.com/protocol/10.1007%2F978-1-0716-0599-8_10
Contract Date Feb 1, 2020