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Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues

Marsit, Nagi M.; Sidney, Laura E.; Branch, Matthew James; Wilson, Samantha L.; Hopkinson, Andrew

Authors

Nagi M. Marsit

Matthew James Branch

Samantha L. Wilson

Andrew Hopkinson



Abstract

Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron-beam, and ethylene oxide protocols are well-established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non-thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.

Journal Article Type Article
Journal Plasma Processes and Polymers
Print ISSN 1612-8850
Electronic ISSN 1612-8869
Publisher Wiley-VCH Verlag
Peer Reviewed Peer Reviewed
APA6 Citation Marsit, N. M., Sidney, L. E., Branch, M. J., Wilson, S. L., & Hopkinson, A. (in press). Terminal sterilization: conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues. Plasma Processes and Polymers, https://doi.org/10.1002/ppap.201600134
DOI https://doi.org/10.1002/ppap.201600134
Keywords Cold plasma; Dielectric barrier discharge; Plasma treatment; Sterilization; Tissue engineering
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/ppap.201600134/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the accepted version of the following article: Marsit NM, Sidney LE, Branch MJ, Wilson SL, and Hopkinson A. Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non-viable biological tissues. Plasma Process Polym. 2016; 9999:e201600134. doi:10.1002/ppap.201600134 which has been published in final form at http://onlinelibrary.wi...ppap.201600134/abstract . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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