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Relationships between cortical myeloarchitecture and electrophysiological networks

Hunt, Benjamin A. E.; Tewarie, Prejaas K.; Mougin, Olivier E.; Geades, Nicolas; Jones, Derek K.; Singh, Krish D.; Morris, Peter G.; Gowland, Penny A.; Brookes, Matthew J.

Authors

Benjamin A. E. Hunt benjamin.hunt@nottingham.ac.uk

Prejaas K. Tewarie prejaas.tewarie@nottingham.ac.uk

Olivier E. Mougin

Derek K. Jones

Krish D. Singh

Peter G. Morris

Penny A. Gowland

Matthew J. Brookes matthew.brookes@nottingham.ac.uk



Abstract

The human brain relies upon the dynamic formation and dissolution of a hierarchy of functional networks to support ongoing cognition. However, how functional connectivities underlying such networks are supported by cortical microstructure remains poorly understood. Recent animal work has demonstrated that electrical activity promotes myelination. Inspired by this, we test a hypothesis that gray-matter myelin is related to electrophysiological connectivity. Using ultra-high field MRI and the principle of structural covariance, we derive a structural network showing how myelin density differs across cortical regions and how separate regions can exhibit similar myeloarchitecture. Building upon recent evidence that neural oscillations mediate connectivity, we use magnetoencephalography to elucidate networks that represent the major electrophysiological pathways of communication in the brain. Finally, we show that a significant relationship exists between our functional and structural networks; this relationship differs as a function of neural oscillatory frequency and becomes stronger when integrating oscillations over frequency bands. Our study sheds light on the way in which cortical microstructure supports functional networks. Further, it paves the way for future investigations of the gray-matter structure/function relationship and its breakdown in pathology.

Journal Article Type Article
Publication Date Nov 22, 2016
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 113
Issue 47
Pages 13510-13515
APA6 Citation Hunt, B. A. E., Tewarie, P. K., Mougin, O. E., Geades, N., Jones, D. K., Singh, K. D., …Brookes, M. J. (2016). Relationships between cortical myeloarchitecture and electrophysiological networks. Proceedings of the National Academy of Sciences, 113(47), 13510-13515. https://doi.org/10.1073/pnas.1608587113
DOI https://doi.org/10.1073/pnas.1608587113
Keywords network, functional connectivity, myelination, magnetoencephalography, MRI
Publisher URL http://www.pnas.org/content/113/47/13510
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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