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Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study

Ratib, Sonia; Walker, Alex J.; Card, Timothy R.; Grainge, Matthew J.


Assistant Professor

Alex J. Walker

Clinical Associate Professor


Background: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported.
Methods: We conducted a cohort study using linked Hospital Episodes Statistics and Office for National Statistics mortality data. We determined the risk of VTE separately for 24 cancer sites following first hospitalisation for cancer (index date) and how this varied by age, proximity from hospital admission, administration of chemotherapy and calendar time.
Results: 3,558,660 patients were hospitalised for cancer between 1998 and 2012. The cancer sites with the highest risk of VTE during initial hospitalisation for cancer were pancreatic (4.9%), ovarian (4%) and liver (3.8%). The three cancer sites with the highest risk of first VTE event within 6 months from discharge, were pancreatic (3.7%), oesophagus (3%) and stomach (2.8%). For most cancers, the risk of VTE within 6 months from discharge was higher amongst patients who underwent chemotherapy compared to those who did not. The impact of age on risk of VTE varied considerably between cancer sites.
Conclusion: The risk of VTE amongst patients hospitalised for cancer varies greatly by cancer site, age, proximity from hospital admission and chemotherapy administration.


Ratib, S., Walker, A. J., Card, T. R., & Grainge, M. J. (2016). Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study. Journal of Hematology and Oncology, 9,

Journal Article Type Article
Acceptance Date Jul 15, 2016
Online Publication Date Jul 26, 2016
Publication Date Jul 26, 2016
Deposit Date Jul 29, 2016
Publicly Available Date Jul 29, 2016
Journal Journal of Hematology and Oncology
Electronic ISSN 1756-8722
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 9
Article Number 60
Keywords Cancer; Venous thrombosis; Hospitalisation; Epidemiology; Chemotherapy
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


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