Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices

Chou, I-Jun; Wang, Huei-Shyong; Whitehouse, William P.; Constantinescu, Cris S.

Abstract

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term treatment is vital to mitigate ongoing neuroinflammation and irreversible neurodegeneration.However, it may be difficult to early differentiate pediatric MS from acute disseminatedencephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD) as they often have atypical presentation that differs from that of adult-onset MS. Thepurpose of this review is to summarize the updated views on diagnostic criteria, imaging, histopathology and treatment choices.

Citation

Chou, I., Wang, H., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), https://doi.org/10.1007/s11910-016-0663-4

• Journal Article Type: Article
• Acceptance Date: Mar 16, 2016
• Online Publication Date: Jun 6, 2016
• Deposit Date: May 31, 2016
• Publicly Available Date: Jun 6, 2016
• Journal: Current Neurology and Neuroscience Reports
• Print ISSN: 1528-4042
• Electronic ISSN: 1534-6293
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 7
• DOI: https://doi.org/10.1007/s11910-016-0663-4
• Keywords: ADEM; CIS; Demyelination; MRI; NMOSD
• Public URL: https://nottingham-repository.worktribe.com/output/796377
• Publisher URL: http://link.springer.com/article/10.1007%2Fs11910-016-0663-4