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The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens

Psifidi, A.; Fife, M.; Howell, J.; Matika, O.; van Diemen, P.M.; Kuo, Richard; Smith, J.; Hockling, P.M.; Salmon, N.; Jones, M.A.; Hume, D.A.; Banos, G.; Stevens, M.P.; Kaiser, P.

Authors

A. Psifidi

M. Fife

J. Howell

O. Matika

P.M. van Diemen

Richard Kuo

J. Smith

P.M. Hockling

N. Salmon

D.A. Hume

G. Banos

M.P. Stevens

P. Kaiser



Abstract

Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially reduce its subsequent entry into the food chain. Campylobacter intestinal colonisation levels are influenced by the host genetics of the chicken. In the present study, two chicken populations were used to investigate the genetic architecture of avian resistance to colonisation: (i) a back-cross of two White Leghorn derived inbred lines [(61 x N) x N] known to differ in resistance to Campylobacter colonisation and (ii) a 9th generation advanced intercross (61 x N) line.

Citation

Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P., Kuo, R., …Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17(1), https://doi.org/10.1186/s12864-016-2612-7

Journal Article Type Article
Acceptance Date Apr 6, 2016
Online Publication Date Apr 18, 2016
Publication Date Apr 18, 2016
Deposit Date Apr 6, 2017
Publicly Available Date Apr 6, 2017
Journal BMC Genomics
Electronic ISSN 1471-2164
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 17
Issue 1
Article Number 293
DOI https://doi.org/10.1186/s12864-016-2612-7
Keywords Campylobacter, Chicken, Colonisation, Genetics, Resistance
Public URL http://eprints.nottingham.ac.uk/id/eprint/41760
Publisher URL http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2612-7
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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