The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens

Psifidi, A.; Fife, M.; Howell, J.; Matika, O.; van Diemen, P.M.; Kuo, Richard; Smith, J.; Hockling, P.M.; Salmon, N.; Jones, M.A.; Hume, D.A.; Banos, G.; Stevens, M.P.; Kaiser, P.

Abstract

Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially reduce its subsequent entry into the food chain. Campylobacter intestinal colonisation levels are influenced by the host genetics of the chicken. In the present study, two chicken populations were used to investigate the genetic architecture of avian resistance to colonisation: (i) a back-cross of two White Leghorn derived inbred lines [(61 x N) x N] known to differ in resistance to Campylobacter colonisation and (ii) a 9th generation advanced intercross (61 x N) line.

Citation

Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P., Kuo, R., Smith, J., Hockling, P., Salmon, N., Jones, M., Hume, D., Banos, G., Stevens, M., & Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17(1), Article 293. https://doi.org/10.1186/s12864-016-2612-7

• Journal Article Type: Article
• Acceptance Date: Apr 6, 2016
• Online Publication Date: Apr 18, 2016
• Publication Date: Apr 18, 2016
• Deposit Date: Apr 6, 2017
• Publicly Available Date: Apr 6, 2017
• Journal: BMC Genomics
• Electronic ISSN: 1471-2164
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 1
• Article Number: 293
• DOI: https://doi.org/10.1186/s12864-016-2612-7
• Keywords: Campylobacter, Chicken, Colonisation, Genetics, Resistance
• Public URL: https://nottingham-repository.worktribe.com/output/784771
• Publisher URL: http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2612-7
• Contract Date: Apr 6, 2017