Skip to main content

Research Repository

Advanced Search

Decentralised clinical trials in multiple sclerosis research

Garjani, Afagh; Liu, Brandon Jun-Yu; Allen, Christopher Martin; Gunzler, Douglas David; Gerry, Stephen William; Planchon, Sarah Marie; das Nair, Roshan; Chataway, Jeremy; Tallantyre, Emma C; Ontaneda, Daniel; Evangelou, Nikos

Decentralised clinical trials in multiple sclerosis research Thumbnail


Afagh Garjani

Brandon Jun-Yu Liu

Christopher Martin Allen

Douglas David Gunzler

Stephen William Gerry

Sarah Marie Planchon

Professor of Clinical Psychology and Neuropsychology

Jeremy Chataway

Emma C Tallantyre

Daniel Ontaneda


Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their conduct. Advances in digital and mobile technologies in recent years have facilitated this process and the first RCTs with decentralised elements became possible. Decentralised clinical trials (DCTs) are conducted remotely, enabling participation of a more heterogeneous population who can participate in research activities from different locations and at their convenience. DCTs also rely on digital and mobile technologies which allows for more flexible and frequent assessments. While hospitals quickly adapted to e-health and telehealth assessments during the COVID-19 pandemic, the conduct of conventional RCTs was profoundly disrupted. In this paper, we review the existing evidence and gaps in knowledge in the design and conduct of DCTs in MS.


Garjani, A., Liu, B. J.-Y., Allen, C. M., Gunzler, D. D., Gerry, S. W., Planchon, S. M., …Evangelou, N. (2023). Decentralised clinical trials in multiple sclerosis research. Multiple Sclerosis Journal, 29(3), 317-325.

Journal Article Type Article
Acceptance Date Apr 19, 2022
Online Publication Date Jun 23, 2022
Publication Date 2023-03
Deposit Date Apr 21, 2022
Publicly Available Date Apr 21, 2022
Journal Multiple Sclerosis Journal
Print ISSN 1352-4585
Electronic ISSN 1477-0970
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 29
Issue 3
Pages 317-325
Keywords Neurology (clinical); Neurology
Public URL
Publisher URL


You might also like

Downloadable Citations