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Glycosylated notch and cancer

Pakkiriswami, Shanmugasundaram; Couto, Africa; Nagarajan, Usha; Georgiou, Marios


Shanmugasundaram Pakkiriswami

Africa Couto

Usha Nagarajan


Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.


Pakkiriswami, S., Couto, A., Nagarajan, U., & Georgiou, M. (2016). Glycosylated notch and cancer. Frontiers in Oncology, 6(37),

Journal Article Type Article
Acceptance Date Feb 5, 2016
Publication Date Feb 18, 2016
Deposit Date Apr 20, 2016
Publicly Available Date Apr 20, 2016
Journal Frontiers in Oncology
Electronic ISSN 2234-943X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 6
Issue 37
Keywords Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor
Public URL
Publisher URL


fonc-06-00037 (1).pdf (551 Kb)

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