Glycosylated notch and cancer

Pakkiriswami, Shanmugasundaram; Couto, Africa; Nagarajan, Usha; Georgiou, Marios

doi:10.3389/fonc.2016.00037

Glycosylated notch and cancer

Pakkiriswami, Shanmugasundaram; Couto, Africa; Nagarajan, Usha; Georgiou, Marios

Authors

Shanmugasundaram Pakkiriswami

Africa Couto

Usha Nagarajan

MARIOS GEORGIOU MARIOS.GEORGIOU@NOTTINGHAM.AC.UK
Assistant Professor

Abstract

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.

Citation

Pakkiriswami, S., Couto, A., Nagarajan, U., & Georgiou, M. (2016). Glycosylated notch and cancer. Frontiers in Oncology, 6(37), https://doi.org/10.3389/fonc.2016.00037

Journal Article Type	Article
Acceptance Date	Feb 5, 2016
Publication Date	Feb 18, 2016
Deposit Date	Apr 20, 2016
Publicly Available Date	Apr 20, 2016
Journal	Frontiers in Oncology
Electronic ISSN	2234-943X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	6
Issue	37
DOI	https://doi.org/10.3389/fonc.2016.00037
Keywords	Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor
Public URL	https://nottingham-repository.worktribe.com/output/775915
Publisher URL	http://journal.frontiersin.org/article/10.3389/fonc.2016.00037/full