High throughput screening for discovery of materials that control stem cell fate

Patel, Asha K.; Tibbitt, Mark; Celiz, Adam D.; Davies, Martyn C.; Langer, Robert; Denning, Chris; Alexander, Morgan R.; Anderson, Daniel G.

Abstract

Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.

Citation

Patel, A. K., Tibbitt, M., Celiz, A. D., Davies, M. C., Langer, R., Denning, C., …Anderson, D. G. (2016). High throughput screening for discovery of materials that control stem cell fate. Current Opinion in Solid State and Materials Science, 20(4), 202-211. https://doi.org/10.1016/j.cossms.2016.02.002

• Journal Article Type: Article
• Acceptance Date: Feb 7, 2016
• Online Publication Date: Feb 22, 2016
• Publication Date: 2016-08
• Deposit Date: Feb 24, 2016
• Publicly Available Date: Feb 24, 2016
• Journal: Current Opinion in Solid State and Materials Science
• Print ISSN: 1359-0286
• Electronic ISSN: 1879-0348
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 4
• Pages: 202-211
• DOI: https://doi.org/10.1016/j.cossms.2016.02.002
• Keywords: Stem cells; Differentiation; Biomaterials; High throughput screening; 3D
• Public URL: https://nottingham-repository.worktribe.com/output/775613
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1359028616300055
• Additional Information: This article is maintained by: Elsevier; Article Title: High throughput screening for discovery of materials that control stem cell fate; Journal Title: Current Opinion in Solid State and Materials Science; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.cossms.2016.02.002; Content Type: article; Copyright: © 2016 The Authors. Published by Elsevier Ltd.