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High throughput screening for discovery of materials that control stem cell fate

Patel, Asha K.; Tibbitt, Mark; Celiz, Adam D.; Davies, Martyn C.; Langer, Robert; Denning, Chris; Alexander, Morgan R.; Anderson, Daniel G.

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Authors

Asha K. Patel

Mark Tibbitt

Adam D. Celiz

Martyn C. Davies

Robert Langer

CHRIS DENNING chris.denning@nottingham.ac.uk
Professor of Stem Cell Biology

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MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces

Daniel G. Anderson



Abstract

Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.

Journal Article Type Article
Acceptance Date Feb 7, 2016
Online Publication Date Feb 22, 2016
Publication Date 2016-08
Deposit Date Feb 24, 2016
Publicly Available Date Feb 24, 2016
Journal Current Opinion in Solid State and Materials Science
Print ISSN 1359-0286
Electronic ISSN 1879-0348
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 20
Issue 4
Pages 202-211
DOI https://doi.org/10.1016/j.cossms.2016.02.002
Keywords Stem cells; Differentiation; Biomaterials; High throughput screening; 3D
Public URL https://nottingham-repository.worktribe.com/output/775613
Publisher URL http://www.sciencedirect.com/science/article/pii/S1359028616300055
Additional Information This article is maintained by: Elsevier; Article Title: High throughput screening for discovery of materials that control stem cell fate; Journal Title: Current Opinion in Solid State and Materials Science; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.cossms.2016.02.002; Content Type: article; Copyright: © 2016 The Authors. Published by Elsevier Ltd.

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