Chang-Fu Kuo
Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan
Kuo, Chang-Fu; Grainge, Matthew J; See, Lai-Chu; Yu, Kuang-Hui; Luo, Shue-Fen; Valdes, Ana M.; Zhang, Weiya; Doherty, Michael
Authors
Dr MATTHEW GRAINGE MATTHEW.GRAINGE@NOTTINGHAM.AC.UK
Associate Professor
Lai-Chu See
Kuang-Hui Yu
Shue-Fen Luo
Professor ANA VALDES Ana.Valdes@nottingham.ac.uk
Professor of Molecular & Genetic Epidemiology
Professor WEIYA ZHANG WEIYA.ZHANG@NOTTINGHAM.AC.UK
Professor of Epidemiology
Michael Doherty
Abstract
© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility. Results: RRs for gout were significantly higher in individuals with affected first-degree relatives (men, 1.91 (95% CI 1.90 to 1.93); women, 1.97 (95% CI 1.94 to 1.99)) and also in those with affected second-degree relatives (men, 1.27 (95% CI 1.23 to 1.31); women, 1.40 (95% CI 1.35 to 1.46)). RRs (95% CIs) for individuals with an affected twin, sibling, offspring, parent, grandchild, nephew/niece, uncle/aunt and grandparent were 8.02 (6.95 to 9.26), 2.59 (2.54 to 2.63), 1.96 (1.95 to 1.97), 1.93 (1.91 to 1.94), 1.48 (1.43 to 1.53), 1.40 (1.32 to 1.47), 1.31 (1.24 to 1.39), and 1.26 (1.21 to 1.30), respectively. The relative contributions of heritability, common and non-shared environmental factors to phenotypic variance of gout were 35.1, 28.1 and 36.8% in men and 17.0, 18.5 and 64.5% in women, respectively. Conclusions: This population-based study confirms that gout aggregates within families. The risk of gout is higher in people with a family history. Genetic and environmental factors contribute to gout aetiology, and the relative contributions are sexually dimorphic.
Citation
Kuo, C.-F., Grainge, M. J., See, L.-C., Yu, K.-H., Luo, S.-F., Valdes, A. M., Zhang, W., & Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 3, 2013 |
Online Publication Date | Nov 21, 2013 |
Publication Date | 2015-02 |
Deposit Date | Apr 19, 2017 |
Publicly Available Date | Apr 19, 2017 |
Journal | Annals of the Rheumatic Diseases |
Print ISSN | 0003-4967 |
Electronic ISSN | 1468-2060 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 74 |
Issue | 2 |
Pages | 369-374 |
DOI | https://doi.org/10.1136/annrheumdis-2013-204067 |
Keywords | Adolescent, Adult, Age distribution, Aged, Aged, 80 and over, Cross-sectional studies, Environment, Female, Genetic predisposition to disease, Gout/epidemiology/genetics, Humans, Male, Middle Aged, Prevalence, Sex distribution, Socioeconomic factors, Taiw |
Public URL | https://nottingham-repository.worktribe.com/output/743582 |
Publisher URL | http://ard.bmj.com/content/74/2/369 |
Contract Date | Apr 19, 2017 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
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