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The functional repertoire of survivin's tails

Wheatley, Sally P.

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Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has received much attention as a potential oncotherapeutic target. Nevertheless, many questions regarding its exact role at the molecular level remain to be elucidated. In this study we ask whether the extreme C- and NH2 termini of survivin are required for it to carry out its cytoprotective and mitotic duties. When assayed for their ability to act as a cytoprotectant, both survivin1-120 and survivin11-142 were able to protect cells against TRAIL-mediated apoptosis, but when challenged with irradiation cells expressing survivin11-142 had no survival advantage. During mitosis, however, removing the NH2 terminal 10 amino acids (survivin11-142) had no apparent effect but truncating 22 amino acids from the C-terminus (survivin1-120) prevented survivin from transferring to the midzone microtubules during anaphase. Collectively the data herein presented suggest that the C-terminus is required for cell division, and that the NH2 terminus is dispensable for apoptosis and mitosis but required for protection from irradiation.

Journal Article Type Article
Acceptance Date Oct 20, 2014
Online Publication Date Jan 21, 2015
Publication Date Jan 15, 2015
Deposit Date Jul 19, 2016
Publicly Available Date Jul 19, 2016
Journal Cell Cycle
Print ISSN 1538-4101
Electronic ISSN 1551-4005
Publisher Taylor & Francis Open
Peer Reviewed Peer Reviewed
Volume 14
Issue 2
Keywords Survivin, Mitosis, Apoptosis, Irradiation, Cancer
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