Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D.; Kurlak, L.O.; Whitley, Guy S.; Cartwright, Judith E.; Broughton Pipkin, Fiona; Tribe, Rachel M.

Abstract

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

Citation

Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

• Journal Article Type: Article
• Acceptance Date: Feb 20, 2014
• Online Publication Date: Mar 3, 2014
• Publication Date: May 31, 2014
• Deposit Date: Jul 21, 2017
• Publicly Available Date: Jul 21, 2017
• Journal: Placenta
• Print ISSN: 0143-4004
• Electronic ISSN: 1532-3102
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 5
• DOI: https://doi.org/10.1016/j.placenta.2014.02.008
• Keywords: Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE
• Public URL: https://nottingham-repository.worktribe.com/output/728006
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0143400414000824
• Contract Date: Jul 21, 2017