Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model
Ivell, Richard; Dai, Yanzhenzi; Mann, Navdeep; Anand-Ivell, Ravinder
RAVINDER ANAND-IVELL Ravinder.Anandemail@example.com
Steroidogenic tissues such as the ovary, testes or adrenal glands are paradoxical in that they often indicate actions of steroid hormones within a dynamic range of ligand concentration in a high nanomolar or even micromolar level, i.e. at the natural concentrations existing within those organs. Yet ligand-activated nuclear steroid receptors act classically by direct interaction with DNA in the picomolar or low nanomolar range. Moreover, global genomic studies suggest that less than 40% of steroid-regulated genes involve classical responsive elements in gene promoter regions. The bovine oxytocin gene is a key element in the maternal recognition of pregnancy in ruminants and is regulated via an SF1 site in its proximal promoter. This gene is also regulated by steroids acting in a non-classical manner, involving nuclear receptors which do not interact directly with DNA. Dose-response relationships for these actions are in the high nanomolar range. Similar ‘steroid sensing’ mechanisms may prevail for other SF1-regulated genes and predict alternative pathways by which environmental endocrine disruptors might influence the functioning of steroid-producing organs and hence indirectly the steroid-dependent control of physiology and development.
Ivell, R., Dai, Y., Mann, N., & Anand-Ivell, R. (2014). Non-classical mechanisms of steroid sensing in the ovary: lessons from the bovine oxytocin model. Molecular and Cellular Endocrinology, 382(1), doi:10.1016/j.mce.2013.04.016
|Journal Article Type||Article|
|Acceptance Date||Apr 27, 2013|
|Online Publication Date||Apr 28, 2013|
|Publication Date||Jan 25, 2014|
|Deposit Date||Oct 24, 2017|
|Journal||Molecular and Cellular Endocrinology|
|Peer Reviewed||Peer Reviewed|
|Keywords||Oxytocin ; Non-classical steroid signaling ;Oxytocin receptor ; Estrogen receptor-alpha ; Estrogen receptor-beta ;Bovine ovary|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf|
This file is under embargo due to copyright reasons.
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