JANET DALY janet.daly@nottingham.ac.uk
Professor of Viral Zoonoses
Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy
Daly, Janet M.; Elton, Debra
Authors
Debra Elton
Abstract
The calculation of pepitope values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the pepitope value to equine influenza vaccine strain selection was assessed. There was a negative correlation between pepitope value and vaccine efficacy for pairs of vaccine and challenge strains used in cross-protection studies in ponies that just reached statistical significance (p = 0.046) only if one pair of viruses was excluded from the analysis. Thus the pepitope value has potential to provide additional data to consider in the decision-making process for updating equine influenza vaccine strains. However, further work is required to define the epitopes of the equine H3N8 haemagglutinin protein recognised by equine antibodies, which could lead to refinement of the pepitope value calculation. Furthermore, other factors such as vaccine potency and virulence of circulating strains may also influence vaccine efficacy.
Citation
Daly, J. M., & Elton, D. (2013). Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy. Vaccine, 31(51), https://doi.org/10.1016/j.vaccine.2013.06.070
Journal Article Type | Article |
---|---|
Publication Date | Dec 9, 2013 |
Deposit Date | Mar 24, 2014 |
Publicly Available Date | Mar 29, 2024 |
Journal | Vaccine |
Print ISSN | 0264-410X |
Electronic ISSN | 0264-410X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 51 |
DOI | https://doi.org/10.1016/j.vaccine.2013.06.070 |
Public URL | https://nottingham-repository.worktribe.com/output/720513 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S0264410X13008797 |
Files
1-s2.0-S0264410X13008797-main.pdf
(350 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
You might also like
Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances
(2023)
Journal Article
Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness
(2023)
Journal Article
Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt
(2022)
Journal Article
Epidemiology of equine influenza in the Maghreb area
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search