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Both, toxin A and toxin B, are important in Clostridium difficile infection

Kuehne, Sarah A.; Cartman, Stephen T.; Minton, Nigel P.


Sarah A. Kuehne

Stephen T. Cartman


The bacterium Clostridium difficile is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of C. difficile are two large toxins, A and B. Over the years there has been some debate over the respective roles and importance of these two toxins. To address this, we recently constructed stable toxin mutants of C. difficile and found that they were virulent if either toxin A or toxin B was functional. This underlined the importance of each toxin and the necessity to consider both when developing countermeasures against Clostridium difficile infection (CDI). In this article we discuss our findings in the context of previous work and outline some of the challenges which face the field as a result.


Kuehne, S. A., Cartman, S. T., & Minton, N. P. (2011). Both, toxin A and toxin B, are important in Clostridium difficile infection. Gut Microbes, 2(4),

Journal Article Type Article
Publication Date Jul 1, 2011
Deposit Date Apr 29, 2014
Publicly Available Date Apr 29, 2014
Journal Gut Microbes
Print ISSN 1949-0976
Electronic ISSN 1949-0976
Publisher Taylor & Francis Open
Peer Reviewed Peer Reviewed
Volume 2
Issue 4
Keywords Clostridium difficile, Toxin A, Toxin B, Clostridium difficile infection
Public URL
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