Sarah A. Kuehne
Both, toxin A and toxin B, are important in Clostridium difficile infection
Kuehne, Sarah A.; Cartman, Stephen T.; Minton, Nigel P.
Authors
Stephen T. Cartman
Professor NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Applied Molecular Microbiology
Abstract
The bacterium Clostridium difficile is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of C. difficile are two large toxins, A and B. Over the years there has been some debate over the respective roles and importance of these two toxins. To address this, we recently constructed stable toxin mutants of C. difficile and found that they were virulent if either toxin A or toxin B was functional. This underlined the importance of each toxin and the necessity to consider both when developing countermeasures against Clostridium difficile infection (CDI). In this article we discuss our findings in the context of previous work and outline some of the challenges which face the field as a result.
Citation
Kuehne, S. A., Cartman, S. T., & Minton, N. P. (2011). Both, toxin A and toxin B, are important in Clostridium difficile infection. Gut Microbes, 2(4), https://doi.org/10.4161/gmic.2.4.16109
Journal Article Type | Article |
---|---|
Publication Date | Jul 1, 2011 |
Deposit Date | Apr 29, 2014 |
Publicly Available Date | Apr 29, 2014 |
Journal | Gut Microbes |
Print ISSN | 1949-0976 |
Electronic ISSN | 1949-0984 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 4 |
DOI | https://doi.org/10.4161/gmic.2.4.16109 |
Keywords | Clostridium difficile, Toxin A, Toxin B, Clostridium difficile infection |
Public URL | https://nottingham-repository.worktribe.com/output/707556 |
Publisher URL | https://www.landesbioscience.com/journals/gutmicrobes/article/16109/ |
Files
Minton_Both_toxin_A_and_toxin_B_are_important.pdf
(226 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
A universal mariner transposon system for forward genetic studies in the genus Clostridium
(2015)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search