Yi Zhang
The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study
Zhang, Yi; Luo, Qiang; Huang, Chu-Chung; Lo, Chun-Yi Zac; Langley, Christelle; Desrivi�res, Sylvane; Quinlan, Erin Burke; Banaschewski, Tobias; Millenet, Sabina; Bokde, Arun L W; Flor, Herta; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Artiges, Eric; Paill�re-Martinot, Marie-Laure; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Fr�hner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Tsai, Shih-Jen; Lin, Ching-Po; Bullmore, Ed; Schumann, Gunter; Sahakian, Barbara J; Feng, Jianfeng; for the IMAGEN consortium
Authors
Qiang Luo
Chu-Chung Huang
Chun-Yi Zac Lo
Christelle Langley
Sylvane Desrivi�res
Erin Burke Quinlan
Tobias Banaschewski
Sabina Millenet
Arun L W Bokde
Herta Flor
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Jean-Luc Martinot
Eric Artiges
Marie-Laure Paill�re-Martinot
Frauke Nees
Dimitri Papadopoulos Orfanos
Luise Poustka
Juliane H Fr�hner
Michael N Smolka
Henrik Walter
Robert Whelan
Shih-Jen Tsai
Ching-Po Lin
Ed Bullmore
Gunter Schumann
Barbara J Sahakian
Jianfeng Feng
for the IMAGEN consortium
Abstract
Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in the male brain before middle age but became weaker after that, when compared with the female brain, after systematic testing of potentially confounding effects. We defined a brain gender continuum by estimating the likelihood of an observed functional connectivity matrix to represent a male brain. We found that participants mapped at the center of this continuum had fewer internalizing symptoms compared with those at the 2 extreme ends. These findings suggest a novel hypothesis proposing that there exists a neuroimaging concept of androgyny using the brain gender continuum, which may be associated with better mental health in a similar way to psychological androgyny.
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 25, 2020 |
Online Publication Date | Jan 20, 2021 |
Publication Date | May 10, 2021 |
Deposit Date | Jun 18, 2021 |
Publicly Available Date | Jun 18, 2021 |
Journal | Cerebral Cortex |
Print ISSN | 1047-3211 |
Electronic ISSN | 1460-2199 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 6 |
Pages | 3021-3033 |
DOI | https://doi.org/10.1093/cercor/bhaa408 |
Keywords | Cognitive Neuroscience; Cellular and Molecular Neuroscience |
Public URL | https://nottingham-repository.worktribe.com/output/5690723 |
Publisher URL | https://academic.oup.com/cercor/article/31/6/3021/6104776 |
Files
Penny Gowland Output_The Human Brain
(1.5 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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