Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients

Damion, Robin A.; Knight, Michael J.; McGarry, Bryony L.; Bosnell, Rose; Jezzard, Peter; Harston, George W.J.; Carone, Davide; Kennedy, James; El-Tawil, Salwa; Elliot, Jennifer; Muir, Keith W; Clatworthy, Philip; Kauppinen, Risto A.

Abstract

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T2 relaxation time changes in ischaemic brain such that T2 in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T2 in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T2 on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We studied whether T2 changes in the two main cerebral tissue types, i.e. in grey matter (GM) and white matter (WM), would differ in stroke.

Citation

Damion, R. A., Knight, M. J., McGarry, B. L., Bosnell, R., Jezzard, P., Harston, G. W., Carone, D., Kennedy, J., El-Tawil, S., Elliot, J., Muir, K. W., Clatworthy, P., & Kauppinen, R. A. (2019). Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), Article 095016. https://doi.org/10.1088/1361-6560/ab1442

• Journal Article Type: Article
• Acceptance Date: Mar 28, 2019
• Online Publication Date: Apr 29, 2019
• Publication Date: Apr 29, 2019
• Deposit Date: Jul 27, 2021
• Publicly Available Date: Dec 9, 2022
• Journal: Physics in Medicine & Biology
• Print ISSN: 0031-9155
• Electronic ISSN: 1361-6560
• Publisher: IOP Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 9
• Article Number: 095016
• DOI: https://doi.org/10.1088/1361-6560/ab1442
• Public URL: https://nottingham-repository.worktribe.com/output/4982388
• Publisher URL: https://iopscience.iop.org/article/10.1088/1361-6560/ab1442