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Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients

Damion, Robin A.; Knight, Michael J.; McGarry, Bryony L.; Bosnell, Rose; Jezzard, Peter; Harston, George W.J.; Carone, Davide; Kennedy, James; El-Tawil, Salwa; Elliot, Jennifer; Muir, Keith W; Clatworthy, Philip; Kauppinen, Risto A.

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Authors

Michael J. Knight

Bryony L. McGarry

Rose Bosnell

Peter Jezzard

George W.J. Harston

Davide Carone

James Kennedy

Salwa El-Tawil

Jennifer Elliot

Keith W Muir

Philip Clatworthy

Risto A. Kauppinen



Contributors

Abstract

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T2 relaxation time changes in ischaemic brain such that T2 in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T2 in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T2 on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We studied whether T2 changes in the two main cerebral tissue types, i.e. in grey matter (GM) and white matter (WM), would differ in stroke.

Citation

Damion, R. A., Knight, M. J., McGarry, B. L., Bosnell, R., Jezzard, P., Harston, G. W., …Kauppinen, R. A. (2019). Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients. Physics in Medicine and Biology, 64(9), Article 095016. https://doi.org/10.1088/1361-6560/ab1442

Journal Article Type Article
Acceptance Date Mar 28, 2019
Online Publication Date Apr 29, 2019
Publication Date Apr 29, 2019
Deposit Date Jul 27, 2021
Publicly Available Date Mar 28, 2024
Journal Physics in Medicine & Biology
Print ISSN 0031-9155
Electronic ISSN 1361-6560
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 64
Issue 9
Article Number 095016
DOI https://doi.org/10.1088/1361-6560/ab1442
Public URL https://nottingham-repository.worktribe.com/output/4982388
Publisher URL https://iopscience.iop.org/article/10.1088/1361-6560/ab1442

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