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Imaging of nuclear magnetic resonance spin-lattice relaxation activation energy in cartilage

Foster, R. J.; Damion, R. A.; Ries, M. E.; Smye, S. W.; McGonagle, D. G.; Binks, D. A.; Radjenovic, A.

Authors

R. J. Foster

M. E. Ries

S. W. Smye

D. G. McGonagle

D. A. Binks

A. Radjenovic



Abstract

Samples of human and bovine cartilage have been examined using magnetic resonance imaging to determine the proton nuclearmagnetic resonance spin-lattice relaxation time, T1, as a function of depth within the cartilage tissue. T1 was measured at five to seven temperatures between 8 and 38°C. From this, it is shown that the T1 relaxation time is well described by Arrhenius-type behaviour and the activation energy of the relaxation process is quantified. The activation energy within the cartilage is approximately 11±2kJmol-1 with this notably being less than that for both pure water (16.6±0.4 kJ mol-1) and the phosphate-buffered solution in which the cartilage was immersed (14.7±1.0 kJ mol-1). It is shown that this activation energy increases as a function of depth in the cartilage. It is known that cartilage composition varies with depth, and hence, these results have been interpreted in terms of the structure within the cartilage tissue and the association of the water with the macromolecular constituents of the cartilage.

Citation

Foster, R. J., Damion, R. A., Ries, M. E., Smye, S. W., McGonagle, D. G., Binks, D. A., & Radjenovic, A. (2018). Imaging of nuclear magnetic resonance spin-lattice relaxation activation energy in cartilage. Royal Society Open Science, 5(7), https://doi.org/10.1098/rsos.180221

Journal Article Type Article
Acceptance Date May 29, 2018
Online Publication Date Jul 11, 2018
Publication Date Jul 11, 2018
Deposit Date Dec 5, 2022
Publicly Available Date Dec 7, 2022
Journal Royal Society Open Science
Electronic ISSN 2054-5703
Publisher The Royal Society
Peer Reviewed Peer Reviewed
Volume 5
Issue 7
DOI https://doi.org/10.1098/rsos.180221
Public URL https://nottingham-repository.worktribe.com/output/14321087
Publisher URL https://royalsocietypublishing.org/doi/10.1098/rsos.180221

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