Thomas M Drake
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study
Drake, Thomas M; Docherty, Annemarie B; Harrison, Ewen M; Quint, Jennifer K; Adamali, Huzaifa; Agnew, Sarah; Babu, Suresh; Barber, Christopher M; Barratt, Shaney; Bendstrup, Elisabeth; Bianchi, Stephen; Castillo Villegas, Diego; Chaudhuri, Nazia; Chua, Felix; Coker, Robina; Chang, William; Cranshaw, Anjali; Crowley, Louise E.; Dosanjh, Davinder; Fiddler, Christine A; Forrest, Ian A.; George, Peter M; Gibbons, Michael A; Groom, Katherine; Haney, Sarah; Hart, Simon P; Heiden, Emily; Henry, Michael; Ho, Ling-Pei; Hoyles, Rachel K; Hutchinson, John; Hurley, Killian; Jones, Mark G; Jones, Steve; Kokosi, Maria; Kreuter, Michael; Mackay, Laura S; Mahendran, Siva; Margaritopoulos, George; Molina-Molina, Maria; Molyneaux, Philip L; O'Brien, Aidan; O'Reilly, Katherine; Packham, Alice; Parfrey, Helen; Poletti, Venerino; Porter, Joanna C.; Renzoni, Elisabetta; Rivera-Ortega, Pilar; Russell, Anne-Marie; Saini, Gauri; Spencer, Lisa G; Stella, Giulia M.; Stone, Helen; Sturney, Sharon; Thickett, David...
Authors
Annemarie B Docherty
Ewen M Harrison
Jennifer K Quint
Huzaifa Adamali
Sarah Agnew
Suresh Babu
Christopher M Barber
Shaney Barratt
Elisabeth Bendstrup
Stephen Bianchi
Diego Castillo Villegas
Nazia Chaudhuri
Felix Chua
Robina Coker
William Chang
Anjali Cranshaw
Louise E. Crowley
Davinder Dosanjh
Christine A Fiddler
Ian A. Forrest
Peter M George
Michael A Gibbons
Katherine Groom
Sarah Haney
Simon P Hart
Emily Heiden
Michael Henry
Ling-Pei Ho
Rachel K Hoyles
John Hutchinson
Killian Hurley
Mark G Jones
Steve Jones
Maria Kokosi
Michael Kreuter
Laura S Mackay
Siva Mahendran
George Margaritopoulos
Maria Molina-Molina
Philip L Molyneaux
Aidan O'Brien
Katherine O'Reilly
Alice Packham
Helen Parfrey
Venerino Poletti
Joanna C. Porter
Elisabetta Renzoni
Pilar Rivera-Ortega
Anne-Marie Russell
Gauri Saini
Lisa G Spencer
Giulia M. Stella
Helen Stone
Sharon Sturney
David Thickett
Muhunthan Thillai
Tim Wallis
Katie Ward
Athol U Wells
Alex West
Melissa Wickremasinghe
Felix Woodhead
Glenn Hearson
Lucy Howard
J. Kenneth Baillie
Peter J M Openshaw
Malcolm G Semple
Iain Stewart
R Gisli Jenkins
ISARIC4C Investigators
Abstract
Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of [less than]80% had an increased risk of death versus patients with FVC ?80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 2.27, 1.39?3.71). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 2, 2020 |
Online Publication Date | Oct 2, 2020 |
Publication Date | Dec 15, 2020 |
Deposit Date | Oct 7, 2020 |
Publicly Available Date | Oct 3, 2021 |
Journal | American Journal of Respiratory and Critical Care Medicine |
Print ISSN | 1073-449X |
Electronic ISSN | 1535-4970 |
Publisher | American Thoracic Society |
Peer Reviewed | Peer Reviewed |
Volume | 202 |
Issue | 12 |
Pages | 1656–1665 |
DOI | https://doi.org/10.1164/rccm.202007-2794oc |
Keywords | Critical Care and Intensive Care Medicine; Pulmonary and Respiratory Medicine |
Public URL | https://nottingham-repository.worktribe.com/output/4939383 |
Publisher URL | https://www.atsjournals.org/doi/10.1164/rccm.202007-2794OC |
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Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study
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