Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies

Ikram, M. Arfan; Licher, Silvan; Ikram, M. Kamran; Leening, Maarten J.G.; Steyerberg, Ewout W.; Yilmaz, Pinar; Stephan, Blossom C.M.; Wolters, Frank J.; Vernooij, Meike W.; Heeringa, Jan; Bindels, Patrick J.E.; Alzheimer�s Disease Neuroimaging Initiative

Abstract

© 2019 American Psychiatric Association. All rights reserved. Objective: Identification of individuals at high risk of dementia is essential for development of prevention strategies, but reliable tools are lacking for risk stratification in the population. The authors developed and validated a prediction model to calculate the 10-year absolute risk of developing dementia in an aging population. Methods: In a large, prospective population-based cohort, data were collected on demographic, clinical, neuropsychological, genetic, and neuroimaging parameters from 2,710 nondemented individuals age 60 or older, examined between 1995 and 2011. A basic and an extended model were derived to predict 10-year risk of dementia while taking into account competing risks from death due to other causes. Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated in the Dutch population-based Epidemiological Prevention Study of Zoetermeer and in the Alzheimer’s Disease Neuroimaging Initiative cohort 1 (ADNI-1). Results: During a follow-up of 20,324 person-years, 181 participants developed dementia. A basic dementia risk model using age, history of stroke, subjective memory decline, and need for assistance with finances or medication yielded a C-statistic of 0.78 (95% CI=0.75, 0.81). Subsequently, an extended model incorporating the basic model and additional cognitive, genetic, and imaging predictors yielded a C-statistic of 0.86 (95% CI=0.83, 0.88). The models performed well in external validation cohorts from Europe and the United States. Conclusions: In community-dwelling individuals, 10-year dementia risk can be accurately predicted by combining information on readily available predictors in the primary care setting. Dementia prediction can be further improved by using data on cognitive performance, genotyping, and brain imaging. These models can be used to identify individuals at high risk of dementia in the population and are able to inform trial design.

Citation

Ikram, M. A., Licher, S., Ikram, M. K., Leening, M. J., Steyerberg, E. W., Yilmaz, P., …Alzheimer’s Disease Neuroimaging Initiative. (2019). Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies. American Journal of Psychiatry, 176(7), 543-551. https://doi.org/10.1176/appi.ajp.2018.18050566

• Journal Article Type: Article
• Acceptance Date: Sep 17, 2018
• Online Publication Date: Dec 11, 2018
• Publication Date: 2019-07
• Deposit Date: Mar 2, 2020
• Publicly Available Date: Mar 3, 2020
• Journal: American Journal of Psychiatry
• Print ISSN: 0002-953X
• Electronic ISSN: 1535-7228
• Publisher: American Psychiatric Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 176
• Issue: 7
• Pages: 543-551
• DOI: https://doi.org/10.1176/appi.ajp.2018.18050566
• Keywords: Psychiatry and Mental health
• Public URL: https://nottingham-repository.worktribe.com/output/4078707
• Publisher URL: https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18050566