Chemical intervention in plant sugar signalling increases yield and resilience

Griffiths, Cara A.; Sagar, Ram; Geng, Yiqun; Primavesi, Lucia F.; Patel, Mitul K.; Passarelli, Melissa K.; Gilmore, Ian S.; Steven, Rory T.; Bunch, Josephine; Paul, Matthew J.; Davis, Benjamin G.

Abstract

The pressing global issue of food insecurity due to population growth, diminishing land and variable climate can only be addressed in agriculture by improving both maximum crop yield potential and resilience. Genetic modification is one potential solution, but has yet to achieve worldwide acceptance, particularly for crops such as wheat. Trehalose-6-phosphate (T6P), a central sugar signal in plants, regulates sucrose use and allocation, underpinning crop growth and development. Here we show that application of a chemical intervention strategy directly modulates T6P levels in planta. Plant-permeable analogues of T6P were designed and constructed based on a 'signalling-precursor' concept for permeability, ready uptake and sunlight-triggered release of T6P in planta. We show that chemical intervention in a potent sugar signal increases grain yield, whereas application to vegetative tissue improves recovery and resurrection from drought. This technology offers a means to combine increases in yield with crop stress resilience. Given the generality of the T6P pathway in plants and other small-molecule signals in biology, these studies suggest that suitable synthetic exogenous small-molecule signal precursors can be used to directly enhance plant performance and perhaps other organism function.

Citation

Griffiths, C. A., Sagar, R., Geng, Y., Primavesi, L. F., Patel, M. K., Passarelli, M. K., Gilmore, I. S., Steven, R. T., Bunch, J., Paul, M. J., & Davis, B. G. (2016). Chemical intervention in plant sugar signalling increases yield and resilience. Nature, 540(7634), 574-578. https://doi.org/10.1038/nature20591

• Journal Article Type: Letter
• Acceptance Date: Oct 28, 2016
• Online Publication Date: Dec 14, 2016
• Publication Date: Dec 22, 2016
• Deposit Date: Nov 2, 2020
• Publicly Available Date: Nov 2, 2020
• Journal: Nature
• Print ISSN: 0028-0836
• Electronic ISSN: 1476-4687
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 540
• Issue: 7634
• Pages: 574-578
• DOI: https://doi.org/10.1038/nature20591
• Public URL: https://nottingham-repository.worktribe.com/output/3788608
• Publisher URL: https://www.nature.com/articles/nature20591
• Additional Information: Received: 2 April 2016; Accepted: 28 October 2016; First Online: 14 December 2016; : A patent has been filed by the University of Oxford and Rothamsted Research and, if licensed, will afford authors royalties in line with standard university practice.